Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 175, Issue -, Pages 248-255Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2018.12.001
Keywords
CpG oligodeoxynucleotide; Hollow gold nanosphere; Self-assembled; Immunostimulation; Photothermal
Funding
- Science and Technology Research Project of Department of Education of Hubei Province [D20181105]
- Opening Project of Key Laboratory of Biomedical Polymers of Ministry of Education at Wuhan University [20160102]
- Opening Project of Key Laboratory of Hubei Province for Coal Conversion and New Carbon Materials (Wuhan University of Science and Technology) [WKDM201706]
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To realize efficiently cellular uptake and enhance the immunostimulation, thiolated cytosine-phosphate-guanine (CpG) oligodeoxynucleotides (ODNs) were self-assembled on hollow gold nanospheres (HGNs) to form CpG-HGNs. The cellular uptake of CpG-HGNs in immune cells was studied in RAW 264.7 cells. Due to the enhanced delivery efficiency, CpG-HGNs exhibited a higher immune stimulatory activity compared with CpG ODNs, resulting in a dramatically enhanced secretion of proinfiammatory cytokines. In addition, CpG-HGNs showed low cytotoxicity in RAW 264.7 cells. CpG-HGNs could potentially realize synergistic photothermal therapy and immunotherapy in vivo.
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