Related references
Note: Only part of the references are listed.Targeting the CDA1/CDA1BP1 Axis Retards Renal Fibrosis in Experimental Diabetic Nephropathy
Zhonglin Chai et al.
DIABETES (2019)
Perioperative THR-184 and AKI after Cardiac Surgery
Jonathan Himmelfarb et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)
Diabetes Reduces Severity of Aortic Aneurysms Depending on the Presence of Cell Division Autoantigen 1 (CDA1)
Jiaze Li et al.
DIABETES (2018)
The relaxin receptor as a therapeutic target - perspectives from evolution Cheek for updates and drug targeting
Ross A. D. Bathgate et al.
PHARMACOLOGY & THERAPEUTICS (2018)
FSP1-specific SMAD2 knockout in renal tubular, endothelial, and interstitial cells reduces fibrosis and epithelial-to-mesenchymal transition in murine STZ-induced diabetic nephropathy
Ivonne Loeffler et al.
CELL AND TISSUE RESEARCH (2018)
Disparities in Chronic Kidney Disease Prevalence among Males and Females in 195 Countries: Analysis of the Global Burden of Disease 2016 Study
Boris Bikbov et al.
NEPHRON (2018)
Anti-TGF-β1 Antibody Therapy in Patients with Diabetic Nephropathy
James Voelker et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)
Signaling Cross Talk between TGF-beta/Smad and Other Signaling Pathways
Kunxin Luo
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)
Non-Smad Signaling Pathways of the TGF-β Family
Ying E. Zhang
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)
Selective activation of epidermal growth factor receptor in renal proximal tubule induces tubulointerstitial fibrosis
Jessica M. Overstreet et al.
FASEB JOURNAL (2017)
Association Between Diabetes and Cause-Specific Mortality in Rural and Urban Areas of China
Fiona Bragg et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)
Blocking TGF-β and β-Catenin Epithelial Crosstalk Exacerbates CKD
Stellor Nlandu-Khodo et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)
Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury
Ying-Ying Wang et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)
Recombinant α-Klotho may be prophylactic and therapeutic for acute to chronic kidney disease progression and uremic cardiomyopathy
Ming Chang Hu et al.
KIDNEY INTERNATIONAL (2017)
Therapeutic miR-21 Silencing Ameliorates Diabetic Kidney Disease in Mice
Make Kolling et al.
MOLECULAR THERAPY (2017)
Pirfenidone suppresses MAPK signalling pathway to reverse epithelial-mesenchymal transition and renal fibrosis
Zhenzhen Li et al.
NEPHROLOGY (2017)
Novel Anti-fibrotic Therapies
Benita L. McVicker et al.
FRONTIERS IN PHARMACOLOGY (2017)
Diabetic Kidney Disease Challenges, Progress, and Possibilities
Radica Z. Alicic et al.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)
Klotho/FGF23 Axis in Chronic Kidney Disease and Cardiovascular Disease
Xiang Lu et al.
KIDNEY DISEASES (2017)
IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040
K. Ogurtsova et al.
DIABETES RESEARCH AND CLINICAL PRACTICE (2017)
Klotho attenuates renal hypertrophy and glomerular injury in Ins2Akita diabetic mice
Hiroyuki Kadoya et al.
CLINICAL AND EXPERIMENTAL NEPHROLOGY (2016)
Changing epidemiology of type 2 diabetes mellitus and associated chronic kidney disease
Merlin C. Thomas et al.
NATURE REVIEWS NEPHROLOGY (2016)
Usefulness of the Hepatocyte Growth Factor as a Predictor of Mortality in Patients Hospitalized With Acute Heart Failure Regardless of Ejection Fraction
Juan-Ignacio Perez-Calvo et al.
AMERICAN JOURNAL OF CARDIOLOGY (2016)
Epidermal Growth Factor Receptor Transactivation: Mechanisms, Pathophysiology, and Potential Therapies in the Cardiovascular System
Steven J. Forrester et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 56 (2016)
Matrix metalloproteinase 9 induces endothelial-mesenchymal transition via Notch activation in human kidney glomerular endothelial cells
Ye Zhao et al.
BMC CELL BIOLOGY (2016)
Decreased plasma α-Klotho predict progression of nephropathy with type 2 diabetic patients
Sang Soo Kim et al.
JOURNAL OF DIABETES AND ITS COMPLICATIONS (2016)
The epidermal growth factor receptor pathway in chronic kidney diseases
Laura R. Harskamp et al.
NATURE REVIEWS NEPHROLOGY (2016)
TGF-β: the master regulator of fibrosis
Xiao-ming Meng et al.
NATURE REVIEWS NEPHROLOGY (2016)
Anti-TGF-β Antibody, 1D11, Ameliorates Glomerular Fibrosis in Mouse Models after the Onset of Proteinuria
Xiaoyan Liang et al.
PLOS ONE (2016)
Structural Biology and Evolution of the TGF-β Family
Andrew P. Hinck et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)
The Discovery and Early Days of TGF-β: A Historical Perspective
Harold L. Moses et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)
Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis
Xiao-Ming Meng et al.
CELL DEATH & DISEASE (2016)
Relationship between Estimated Glomerular Filtration Rate and Cardiovascular Mortality in a Japanese Cohort with Long-Term Follow-Up
Kei Nagai et al.
PLOS ONE (2016)
TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions
Xiaofeng Chen et al.
PLOS ONE (2016)
Late intervention with the small molecule BB3 mitigates postischemic kidney injury
Prakash Narayan et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2016)
BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy
Rui Xi Li et al.
CLINICAL SCIENCE (2015)
50 years forward: mechanisms of hyperglycaemia-driven diabetic complications
Nicholas D. F. Russell et al.
DIABETOLOGIA (2015)
Expression of bone morphogenetic proteins 4, 6 and 7 is downregulated in kidney allografts with interstitial fibrosis and tubular atrophy
Vesna Furic-Cunko et al.
INTERNATIONAL UROLOGY AND NEPHROLOGY (2015)
Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression
Manjeri A. Venkatachalam et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)
Relaxin-2 Does Not Ameliorate Nephropathy in an Experimental Model of Type-1 Diabetes
Thomas Bernd Dschietzig et al.
KIDNEY & BLOOD PRESSURE RESEARCH (2015)
Renal fibrosis is not reduced by blocking transforming growth factor-β signaling in matrix-producing interstitial cells
Surekha Neelisetty et al.
KIDNEY INTERNATIONAL (2015)
Origin of myofibroblasts and cellular events triggering fibrosis
Matthias Mack et al.
KIDNEY INTERNATIONAL (2015)
Diverse origins of the myofibroblast -implications for kidney fibrosis
Lucas L. Falke et al.
NATURE REVIEWS NEPHROLOGY (2015)
Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice
Catherine K. Hathaway et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Smad7 protects against chronic aristolochic acid nephropathy in mice
Xiao-Yu Dai et al.
ONCOTARGET (2015)
Role of bone morphogenetic protein-7 in renal fibrosis
Rui Xi Li et al.
FRONTIERS IN PHYSIOLOGY (2015)
GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF-β-Induced Smad3 Phosphorylation
Jun Ai et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)
Curtailing Endothelial TGF-β Signaling Is Sufficient to Reduce Endothelial-Mesenchymal Transition and Fibrosis in CKD
Sandhya Xavier et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)
Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury
Guillaume Canaud et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2015)
microRNA in the development of diabetic complications
Aaron D. McClelland et al.
CLINICAL SCIENCE (2014)
Epidermal Growth Factor Receptor Inhibition Slows Progression of Diabetic Nephropathy in Association With a Decrease in Endoplasmic Reticulum Stress and an Increase in Autophagy
Ming-Zhi Zhang et al.
DIABETES (2014)
Diabetic Kidney Disease: A Report From an ADA Consensus Conference
Katherine R. Tuttle et al.
DIABETES CARE (2014)
Antiproteinuric effect of pirfenidone in a rat model of anti-glomerular basement membrane glomerulonephritis
Koji Takakura et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2014)
The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatotellular carcinoma
Tatsuo Kido et al.
HUMAN PATHOLOGY (2014)
MicroRNA-214 Antagonism Protects against Renal Fibrosis
Laura Denby et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)
Autophagy Regulates TGF-β Expression and Suppresses Kidney Fibrosis Induced by Unilateral Ureteral Obstruction
Yan Ding et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)
Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis
Bryna S. Man Chow et al.
KIDNEY INTERNATIONAL (2014)
Smad3 signaling activates bone marrow-derived fibroblasts in renal fibrosis
Jiyuan Chen et al.
LABORATORY INVESTIGATION (2014)
The effect of RAAS blockade on the progression of diabetic nephropathy
Sara S. Roscioni et al.
NATURE REVIEWS NEPHROLOGY (2014)
Inflammatory processes in renal fibrosis
Xiao-Ming Meng et al.
NATURE REVIEWS NEPHROLOGY (2014)
Changes in Diabetes-Related Complications in the United States, 1990-2010
Edward W. Gregg et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes
Lakhmir S. Chawla et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Remnant nephron physiology and the progression of chronic kidney disease
H. William Schnaper
PEDIATRIC NEPHROLOGY (2014)
Mechanisms of Epithelial Repair and Regeneration After Acute Kidney Injury
Katja Berger et al.
SEMINARS IN NEPHROLOGY (2014)
Circulating α-Klotho Levels in CKD and Relationship to Progression
Hyoung Rae Kim et al.
AMERICAN JOURNAL OF KIDNEY DISEASES (2013)
Transforming Growth Factor β-1 Stimulates Profibrotic Epithelial Signaling to Activate Pericyte-Myofibroblast Transition in Obstructive Kidney Fibrosis
Ching-Fang Wu et al.
AMERICAN JOURNAL OF PATHOLOGY (2013)
Activation of ERK accelerates repair of renal tubular epithelial cells, whereas it inhibits progression of fibrosis following ischemia/reperfusion injury
Hee-Seong Jang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2013)
Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species
Rohan Samarakoon et al.
CELLULAR SIGNALLING (2013)
Role of the TGF-β/BMP-7/Smad pathways in renal diseases
Xiao-Ming Meng et al.
CLINICAL SCIENCE (2013)
Inflammation and the pathogenesis of diabetic nephropathy
Jun Wada et al.
CLINICAL SCIENCE (2013)
miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes
X. Zhong et al.
DIABETOLOGIA (2013)
Genetic Deficiency of Anti-Aging Gene Klotho Exacerbates Early Nephropathy in STZ-Induced Diabetes in Male Mice
Yi Lin et al.
ENDOCRINOLOGY (2013)
Acute treatment with relaxin protects the kidney against ischaemia/reperfusion injury
Massimo Collino et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2013)
Genetic Deletion of Cell Division Autoantigen 1 Retards Diabetes-Associated Renal Injury
Zhonglin Chai et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)
Epithelial Cell TGF beta Signaling Induces Acute Tubular Injury and Interstitial Inflammation
Madeleine E. Gentle et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)
Kidney Disease and Increased Mortality Risk in Type 2 Diabetes
Maryam Afkarian et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)
Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/β-Catenin Signaling
Lili Zhou et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)
Role of epidermal growth factor receptor in acute and chronic kidney injury
Jinhua Tang et al.
KIDNEY INTERNATIONAL (2013)
Chronic kidney disease: global dimension and perspectives
Vivekanand Jha et al.
LANCET (2013)
Evolving importance of kidney disease: from subspecialty to global health burden
Kai-Uwe Eckardt et al.
LANCET (2013)
Smad7 suppresses renal fibrosis via altering expression of TGF-β/Smad3-regulated microRNAs
Arthur C. K. Chung et al.
MOLECULAR THERAPY (2013)
Origin and function of myofibroblasts in kidney fibrosis
Valerie S. LeBleu et al.
NATURE MEDICINE (2013)
RELAXIN FAMILY PEPTIDES AND THEIR RECEPTORS
R. A. D. Bathgate et al.
PHYSIOLOGICAL REVIEWS (2013)
The Anti-fibrotic Hormone Relaxin is not Reno-protective, Despite Being Active, in an Experimental Model of Type 1 Diabetes
Su Wong et al.
PROTEIN AND PEPTIDE LETTERS (2013)
Renal and Extrarenal Actions of Klotho
Ming Chang Hu et al.
SEMINARS IN NEPHROLOGY (2013)
Transforming growth factor-β1 receptor inhibition preserves glomerulotubular integrity during ureteral obstruction in adults but worsens injury in neonatal mice
Carolina I. Galarreta et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2013)
Macrophage-specific deletion of transforming growth factor-β1 does not prevent renal fibrosis after severe ischemia-reperfusion or obstructive injury
Sarah C. Huen et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2013)
Glycation in diabetic nephropathy
Josephine M. Forbes et al.
AMINO ACIDS (2012)
Role of TGF-beta in chronic kidney disease: an integration of tubular, glomerular and vascular effects
Francisco J. Lopez-Hernandez et al.
CELL AND TISSUE RESEARCH (2012)
Telmisartan Exerts Renoprotective Actions via Peroxisome Proliferator-Activated Receptor-γ/Hepatocyte Growth Factor Pathway Independent of Angiotensin II Type 1 Receptor Blockade
Hiroshi Kusunoki et al.
HYPERTENSION (2012)
Diverse roles of TGF-β receptor II in renal fibrosis and inflammation in vivo and in vitro
Xiao-Ming Meng et al.
JOURNAL OF PATHOLOGY (2012)
EGFR Signaling Promotes TGFβ-Dependent Renal Fibrosis
Jianchun Chen et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2012)
Deleting the TGF-β Receptor Attenuates Acute Proximal Tubule Injury
Leslie Gewin et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2012)
Genetic or Pharmacologic Blockade of EGFR Inhibits Renal Fibrosis
Na Liu et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2012)
Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro
Xiao-Ming Meng et al.
KIDNEY INTERNATIONAL (2012)
Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion
Osamu Asai et al.
KIDNEY INTERNATIONAL (2012)
Prevalence of chronic kidney disease in China: a cross-sectional survey
Luxia Zhang et al.
LANCET (2012)
Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis
Hikaru Sugimoto et al.
NATURE MEDICINE (2012)
Targeting the TGFβ signalling pathway in disease
Rosemary J. Akhurst et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Investigating mechanisms of chronic kidney disease in mouse models
Allison A. Eddy et al.
PEDIATRIC NEPHROLOGY (2012)
MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways
B. Nelson Chau et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
How Many Ways Can a Podocyte Die?
Pierre-Louis Tharaux et al.
SEMINARS IN NEPHROLOGY (2012)
Can We Target Tubular Damage to Prevent Renal Function Decline in Diabetes?
Joseph V. Bonventre
SEMINARS IN NEPHROLOGY (2012)
Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling
Minoru Satoh et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2012)
Genomics and proteomics in liver fibrosis and cirrhosis
Rebekka A. Hannivoort et al.
FIBROGENESIS & TISSUE REPAIR (2012)
Reduced Klotho expression level in kidney aggravates renal interstitial fibrosis
Hidekazu Sugiura et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2012)
Glioma Stem Cell Proliferation and Tumor Growth Are Promoted by Nitric Oxide Synthase-2
Christine E. Eyler et al.
CELL (2011)
Mechanisms of fibrosis: the role of the pericyte
Claudia Schrimpf et al.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2011)
Diabetes Complications: The MicroRNA Perspective
Phillip Kantharidis et al.
DIABETES (2011)
Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
Thomas R. Cox et al.
DISEASE MODELS & MECHANISMS (2011)
Hepatocyte Growth Factor Attenuates Transforming Growth Factor-β-Angiotensin II Crosstalk Through Inhibition of the PTEN/Akt Pathway
Kazuma Iekushi et al.
HYPERTENSION (2011)
Diverse Roles of TGF-beta/Smads in Renal Fibrosis and Inflammation
Hui Yao Lan
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2011)
Fibroblasts and myofibroblasts in renal fibrosis
Soma Meran et al.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2011)
Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice
Shigehiro Doi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Cellular pathophysiology of ischemic acute kidney injury
Joseph V. Bonventre et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Pirfenidone for Diabetic Nephropathy
Kumar Sharma et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)
Smad3-Mediated Upregulation of miR-21 Promotes Renal Fibrosis
Xiang Zhong et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)
Cell division autoantigen 1 enhances signaling and the profibrotic effects of transforming growth factor-beta in diabetic nephropathy
Yugang Tu et al.
KIDNEY INTERNATIONAL (2011)
Scar wars: mapping the fate of epithelial-mesenchymal-myofibroblast transition
Susan E. Quaggin et al.
KIDNEY INTERNATIONAL (2011)
A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis
Howard Trachtman et al.
KIDNEY INTERNATIONAL (2011)
Targeted Deletion of CASK-Interacting Nucleosome Assembly Protein Causes Higher Locomotor and Exploratory Activities
Wen-Chuan Chung et al.
NEUROSIGNALS (2011)
TSPYL2 Is Important for G1 Checkpoint Maintenance upon DNA Damage
Kin Pong Tao et al.
PLOS ONE (2011)
Genetic deficiency of Smad3 protects against murine ischemic acute kidney injury
Karl A. Nath et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2011)
Preservation of Kidney Function with Combined Inhibition of NADPH Oxidase and Angiotensin-Converting Enzyme in Diabetic Nephropathy
Vicki Thallas-Bonke et al.
AMERICAN JOURNAL OF NEPHROLOGY (2010)
Transforming Growth Factor-β1 Induces Smad3-Dependent β1 Integrin Gene Expression in Epithelial-to-Mesenchymal Transition during Chronic Tubulointerstitial Fibrosis
Yi-Chun Yeh et al.
AMERICAN JOURNAL OF PATHOLOGY (2010)
Bone Morphogenetic Protein-7 Inhibits Proximal Tubular Epithelial Cell Smad3 Signaling via Increased SnoN Expression
Dong Dong Luo et al.
AMERICAN JOURNAL OF PATHOLOGY (2010)
Tubular Overexpression of Transforming Growth Factor-β1 Induces Autophagy and Fibrosis but Not Mesenchymal Transition of Renal Epithelial Cells
Robert Koesters et al.
AMERICAN JOURNAL OF PATHOLOGY (2010)
Cellular Maintenance and Repair of the Kidney
Jian-Kan Guo et al.
ANNUAL REVIEW OF PHYSIOLOGY (2010)
E-Cadherin Expression Is Regulated by miR-1921215 by a Mechanism That Is Independent of the Profibrotic Effects of Transforming Growth Factor-β
Bo Wang et al.
DIABETES (2010)
Blockade of Endothelial-Mesenchymal Transition by a Smad3 Inhibitor Delays the Early Development of Streptozotocin-Induced Diabetic Nephropathy
Jinhua Li et al.
DIABETES (2010)
Cell division autoantigen 1 plays a profibrotic role by modulating downstream signalling of TGF-beta in a murine diabetic model of atherosclerosis
Y. Pham et al.
DIABETOLOGIA (2010)
In the absence of renal disease, 20 year mortality risk in type 1 diabetes is comparable to that of the general population: a report from the Pittsburgh Epidemiology of Diabetes Complications Study
T. J. Orchard et al.
DIABETOLOGIA (2010)
Antifibrotic Properties of Relaxin: In Vivo Mechanism of Action in Experimental Renal Tubulointerstitial Fibrosis
Tim D. Hewitson et al.
ENDOCRINOLOGY (2010)
Cellular and molecular basis for the regulation of inflammation by TGF-beta
Akihiko Yoshimura et al.
JOURNAL OF BIOCHEMISTRY (2010)
Role of inflammation in tubulo-interstitial damage associated to obstructive nephropathy
Maria T. Grande et al.
JOURNAL OF INFLAMMATION-LONDON (2010)
Mechanisms of Tubulointerstitial Fibrosis
Michael Zeisberg et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)
Smad2 Protects against TGF-β/Smad3-Mediated Renal Fibrosis
Xiao Ming Meng et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)
Regulation of ion channels by secreted Klotho: mechanisms and implications
Chou-Long Huang
KIDNEY INTERNATIONAL (2010)
An integrative view on the role of TGF-β in the progressive tubular deletion associated with chronic kidney disease
Omar Garcia-Sanchez et al.
KIDNEY INTERNATIONAL (2010)
A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy
Maoyin Pang et al.
KIDNEY INTERNATIONAL (2010)
Renal Medicine 2 Early recognition and prevention of chronic kidney disease
Matthew T. James et al.
LANCET (2010)
Smad Proteins Bind a Conserved RNA Sequence to Promote MicroRNA Maturation by Drosha
Brandi N. Davis et al.
MOLECULAR CELL (2010)
Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury
Li Yang et al.
NATURE MEDICINE (2010)
Connective Tissue Growth Factor-(CTGF, CCN2) - A Marker, Mediator and Therapeutic Target for Renal Fibrosis
Mysore K. Phanish et al.
NEPHRON EXPERIMENTAL NEPHROLOGY (2010)
Expression of Transforming Growth Factor-β1 Limits Renal Ischemia-Reperfusion Injury
Qiunong Guan et al.
TRANSPLANTATION (2010)
Bone Morphogenetic Protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis
Carsten P. Bramlage et al.
BMC NEPHROLOGY (2010)
Mechanism of chronic aristolochic acid nephropathy: role of Smad3
Li Zhou et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2010)
Acute kidney injury: a springboard for progression in chronic kidney disease
Manjeri A. Venkatachalam et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2010)
Relaxin Family Peptide Receptor 1 Activation Stimulates Peroxisome Proliferator-Activated Receptor Gamma
Sudhir Singh et al.
RELAXIN AND RELATED PEPTIDES: FIFTH INTERNATIONAL CONFERENCE (2009)
Ski and SnoN, potent negative regulators of TGF-beta signaling
Julien Deheuninck et al.
CELL RESEARCH (2009)
TGF-beta signaling in vascular biology and dysfunction
Marie-Jose Goumans et al.
CELL RESEARCH (2009)
The Presence and Severity of Chronic Kidney Disease Predicts All-Cause Mortality in Type 1 Diabetes
Per-Henrik Groop et al.
DIABETES (2009)
The role of the EGF family of ligands and receptors in renal development, physiology and pathophysiology
Fenghua Zeng et al.
EXPERIMENTAL CELL RESEARCH (2009)
Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2
Ishanee Mookerjee et al.
FASEB JOURNAL (2009)
Angiotensin II Induces Connective Tissue Growth Factor and Collagen I Expression via Transforming Growth Factor-β-Dependent and -Independent Smad Pathways The Role of Smad3
Fuye Yang et al.
HYPERTENSION (2009)
Association Between Renal Function and Cardiovascular Disease in Patients With Left Ventricular Hypertrophy. VIIDA Study
Lorenzo Facila et al.
JOURNAL OF CLINICAL HYPERTENSION (2009)
The basics of epithelial-mesenchymal transition
Raghu Kalluri et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Pirfenidone Is Renoprotective in Diabetic Kidney Disease
Satish P. RamachandraRao et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)
Circulating transforming growth factor-β1 levels and the risk for kidney disease in African Americans
Manikkam Suthanthiran et al.
KIDNEY INTERNATIONAL (2009)
Fibroblast activation and myofibroblast generation in obstructive nephropathy
Maria T. Grande et al.
NATURE REVIEWS NEPHROLOGY (2009)
BMP-7 fails to attenuate TGF-β1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells
Paul L. Dudas et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2009)
Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice
Arthur C. K. Chung et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2009)
Mechanical forces and TGFβ1 reduce podocyte adhesion through α3β1 integrin downregulation
Cecile Dessapt et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2009)
Differential regulation of E-cadherin and α-smooth muscle actin by BMP 7 in human renal proximal tubule epithelial cells and its implication in renal fibrosis
Mangalakumar Veerasamy et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2009)
ADAM17 upregulation in human renal disease: a role in modulating TGF-α availability?
W. B. Melenhorst et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2009)
Role of transforming growth factor-beta superfamily signaling pathways in human disease
Kelly J. Gordon et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2008)
Differentially expressed nucleolar transforming growth factor-β1 target (DENTT) exhibits an inhibitory role on tumorigenesis
Lana E. Kandalaft et al.
CARCINOGENESIS (2008)
Latent TGF-β1 protects against crescentic glornerulonephritis
Xiao R. Huang et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)
A new look at platelet-derived growth factor in renal disease
Juergen Floege et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)
Fibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition
Elisabeth M. Zeisberg et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)
Angiotensin II activates the Smad pathway during epithelial mesenchymal transdifferentiation
Gisselle Carvajal et al.
KIDNEY INTERNATIONAL (2008)
Activation of Erk1/2 and Akt following unilateral ureteral obstruction
Ana B. Rodriguez-Pena et al.
KIDNEY INTERNATIONAL (2008)
Oral administration of GW788388, an inhibitor of TGF-β type I and II receptor kinases, decreases renal fibrosis
M. Petersen et al.
KIDNEY INTERNATIONAL (2008)
SMAD proteins control DROSHA-mediated microRNA maturation
Brandi N. Davis et al.
NATURE (2008)
BMP-7 and proximal tubule epithelial cells: Activation of multiple signaling pathways reveals a novel anti-fibrotic mechanism
Reza Motazed et al.
PHARMACEUTICAL RESEARCH (2008)
Mice overexpressing latent TGF-β1 are protected against renal fibrosis in obstructive kidney disease
Xiao R. Huang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2008)
Bone morphogenetic protein-7 delays podocyte injury due to high glucose
Laura De Petris et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2007)
Interference with TGF-β signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria
Amy Wang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)
TGF-β activates Erk MAP kinase signalling through direct phosphorylation of ShcA
Matt K. Lee et al.
EMBO JOURNAL (2007)
Pirfenidone slows renal function decline in patients with focal segmental glomerulosclerosis
Monique E. Cho et al.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2007)
Protective effects of peroxisome proliferator-activated receptor γ ligand on apoptosis and hepatocyte growth factor induction in renal ischemia-reperfusion injury
Shigehiro Doi et al.
TRANSPLANTATION (2007)
Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors
Hikaru Sugimoto et al.
DIABETES (2007)
TGF-β in renal injury and disease
Erwin P. Bottinger
SEMINARS IN NEPHROLOGY (2007)
TGF-β signaling in vascular fibrosis
Marta Ruiz-Ortega et al.
CARDIOVASCULAR RESEARCH (2007)
Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21Waf1/Cip1 by activating p53 and MEK/ERK1/2 MAPK pathways
Yugang Tu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Effect of combination therapy with enalapril and the TGF-β antagonist 1D11 in unilateral ureteral obstruction
Maher El Chaar et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)
Endogenous relaxin is a naturally occurring modulator of experimental renal tubulointerstitial fibrosis
Tim D. Hewitson et al.
ENDOCRINOLOGY (2007)
Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma
Sonali Sonnylal et al.
ARTHRITIS AND RHEUMATISM (2007)
Recombinant human anti-transforming growth factor beta 1 antibody therapy in systemic sclerosis - A multicenter, randomized, placebo-controlled phase I/II trial of CAT-192
Christopher P. Denton et al.
ARTHRITIS AND RHEUMATISM (2007)
Histopathology of diabetic nephropathy
Paola Fioretto et al.
SEMINARS IN NEPHROLOGY (2007)
Transforming growth factor-β in human diabetic nephropathy -: Effects of ACE inhibition
Robyn G. Langham et al.
DIABETES CARE (2006)
Renal fibroblasts and myofibroblasts in chronic kidney disease
Frank Strutz et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
ERK, p38, and smad signaling pathways differentially regulate transforming growth factor-β1 autoinduction in proximal tubular epithelial cells
Mei Zhang et al.
AMERICAN JOURNAL OF PATHOLOGY (2006)
IN-1130, a novel transforming growth factor-β type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy
J-A Moon et al.
KIDNEY INTERNATIONAL (2006)
Renal bone morphogenetic protein-7 protects against diabetic nephropathy
Shinong Wang et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors
Haruhiko Ohtsu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)
TGF-β1 induces IL-8 and MCP-1 through a connective tissue growth factor-independent pathway
W Qi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2006)
Stimulation of urinary TGF-β and isoprostanes in response to hyperglycemia in humans
Tracy A. McGowan et al.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
Remodeling of renal interstitial and tubular lesions in pancreas transplant recipients
P Fioretto et al.
KIDNEY INTERNATIONAL (2006)
Hepatocyte growth factor is a downstream effector that mediates the antifibrotic action of peroxisome proliferator-activated receptor-gamma agonists
Yingjian Li et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
Regrow or repair: Potential regenerative therapies for the kidney
Melissa H. Little
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
Renal fibrosis: New insights into the pathogenesis and therapeutics
YH Liu
KIDNEY INTERNATIONAL (2006)
Beneficial effect of TGF beta antagonism in treating diabetic nephropathy depends on when treatment is started
Ariela Benigni et al.
NEPHRON EXPERIMENTAL NEPHROLOGY (2006)
Molecular aspects of regulation of collagen gene expression in fibrosis
RK Bhogal et al.
JOURNAL OF CLINICAL IMMUNOLOGY (2005)
The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway
MHJ Heeg et al.
KIDNEY INTERNATIONAL (2005)
BMP receptor signaling: Transcriptional targets, regulation of signals, and signaling cross-talk
K Miyazono et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2005)
Signaling mechanism of TGF-βl in prevention of renal inflammation:: Role of Smad7
WS Wang et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2005)
Differentially expressed nucleolar TGF-β1 target (DENTT) shows tissue-specific nuclear and cytoplasmic localization and increases TGF-β1-responsive transcription in primates
LL Ozbun et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2005)
Transforming growth factor-β in acute renal failure:: receptor expression, effects on proliferation, cellularity, and vascularization after recovery from injury
KR Spurgeon et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2005)
Pathogenetic mechanisms of diabetic nephropathy
FP Schena et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2005)
Pathways to nephron loss starting from glomerular diseases - Insights from animal models
W Kriz et al.
KIDNEY INTERNATIONAL (2005)
A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition
JW Yang et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2005)
Transforming growth factor-β1 inhibition of vascular smooth muscle cell activation is mediated via Smad3
MW Feinberg et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Transcriptional modification by a CASK-interacting nucleosome assembly protein
GS Wang et al.
NEURON (2004)
Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
AS Go et al.
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo
CS Samuel et al.
ENDOCRINOLOGY (2004)
Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction
K Inazaki et al.
KIDNEY INTERNATIONAL (2004)
Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of action
YH Liu
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2004)
Suppressions of chronic glomerular injuries and TGF-beta(1) production by HGF in attenuation of murine diabetic nephropathy
S Mizuno et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2004)
Relaxin-1-deficient mice develop an age-related progression of renal fibrosis
CS Samuel et al.
KIDNEY INTERNATIONAL (2004)
Advanced glycation end products activate Smad signaling via TGF-beta-dependent and -independent mechanisms: implications for diabetic renal and vascular disease
JH Li et al.
FASEB JOURNAL (2004)
Exogenous bone morphogenetic protein-7 fails to attenuate renal fibrosis in rats with overload proteinuria
Y Ikeda et al.
NEPHRON EXPERIMENTAL NEPHROLOGY (2004)
Hepatocyte growth factor antagonizes the profibrotic action of TGF-β1 in mesangial cells by stabilizing smad transcriptional corepressor TGIF
CS Dai et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2004)
Bone morphogenetic protein-7 signals opposing transforming growth factor β in mesangial cells
SN Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Avβ6 integrin expression in diseased and transplanted kidneys
P Trevillian et al.
KIDNEY INTERNATIONAL (2004)
TSPY, the candidate gonadoblastoma gene on the human Y chromosome, has a widely expressed homologue on the X - implications for Y chromosome evolution
ML Delbridge et al.
CHROMOSOME RESEARCH (2004)
Hepatocyte growth factor modulates matrix metalloproteinases and plasminogen activator/plasmin proteolytic pathways in progressive renal interstitial fibrosis
R Gong et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2003)
Long-term exposure of proximal tubular epithelial cells to glucose induces transforming growth factor-β1 synthesis via an autocrine PDGF loop
D Fraser et al.
AMERICAN JOURNAL OF PATHOLOGY (2003)
Smad3 mediates transforming growth factor-β-induced α-smooth muscle actin expression
B Hu et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2003)
Hepatocyte growth factor suppresses renal interstitial myofibroblast activation and intercepts Smad signal transduction
JW Yang et al.
AMERICAN JOURNAL OF PATHOLOGY (2003)
ACE inhibitors improve diabetic nephropathy through suppression of renal MCP-1
B Amann et al.
DIABETES CARE (2003)
BMP-7 counteracts TGF-β1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
M Zeisberg et al.
NATURE MEDICINE (2003)
Prevalence of kidney damage in Australian adults: The AusDiab Kidney Study
SJ Chadban et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2003)
Mice lacking Smad3 are protected against streptozotocin-induced diabetic glomerulopathy
M Fujimoto et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Regression of microalbuminuria in type 1 diabetes
BA Perkins et al.
NEW ENGLAND JOURNAL OF MEDICINE (2003)
Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure
JV Bonventre
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2003)
Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy
S Wang et al.
KIDNEY INTERNATIONAL (2003)
BMP7 antagonizes TGF-β-dependent fibrogenesis in mesangial cells
SN Wang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2003)
Tubulointerstitial disease: role of ischemia and microvascular disease
T Nakagawa et al.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2003)
Extracellular matrix metabolism in diabetic nephropathy
RM Mason et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2003)
Transforming growth factor-β1 potentiates renal tubular epithelial cell death by a mechanism independent of smad signaling
CS Dai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Differentially expressed nucleolar TGF-β1 target (DENTT) in mouse development
LL Ozbun et al.
DEVELOPMENTAL DYNAMICS (2003)
Delayed administration of hepatocyte growth factor reduces renal fibrosis in obstructive nephropathy
JW Yang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2003)
Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype
XJ Du et al.
CARDIOVASCULAR RESEARCH (2003)
Making sense of latent TGFβ activation
JP Annes et al.
JOURNAL OF CELL SCIENCE (2003)
Reversibility of established diabetic glomerulopathy by anti-TGF-β antibodies in dbldb mice
S Chen et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Hepatocyte growth factor: from diagnosis to clinical applications
H Funakoshi et al.
CLINICA CHIMICA ACTA (2003)
Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models
M Zeisberg et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2003)
Targeted disruption of TGF-beta 1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
M Sato et al.
JOURNAL OF CLINICAL INVESTIGATION (2003)
Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey
J Coresh et al.
AMERICAN JOURNAL OF KIDNEY DISEASES (2003)
Downregulation of Smad transcriptional corepressors SnoN and ski in the fibrotic kidney: An amplification mechanism for TGF-beta 1 signaling
JW Yang et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2003)
Isolation of differentially expressed genes in human heart tissues
GF Sun et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2002)
Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis
CS Samuel et al.
FASEB JOURNAL (2002)
Podocyte number in normotensive type 1 diabetic patients with albuminuria
KE White et al.
DIABETES (2002)
Novel aspects of transforming growth factor-beta in diabetic kidney disease
K Tsuchida et al.
NEPHRON (2002)
Effects of high glucose and TGF-β1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes
MC Iglesias-de la Cruz et al.
KIDNEY INTERNATIONAL (2002)
Independent regulation of transforming growth factor-β1 transcription and translation by glucose and platelet-derived growth factor
D Fraser et al.
AMERICAN JOURNAL OF PATHOLOGY (2002)
Evidence that fibroblasts derive from epithelium during tissue fibrosis
M Iwano et al.
JOURNAL OF CLINICAL INVESTIGATION (2002)
Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable
P Levéen et al.
BLOOD (2002)
Transforming growth factor-β induces renal epithelial jagged-1 expression in fibrotic disease
J Morissey et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2002)
Expression of differentially expressed nucleolar transforming growth factor-β1 target (DENTT) in adult mouse tissues
A Martínez et al.
DEVELOPMENTAL DYNAMICS (2002)
Expression of endoglin in human mesangial cells: modulation of extracellular matrix synthesis
L Diez-Marques et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2002)
Transforming growth factor-β signaling through the Smad pathway:: Role in extracellular matrix gene expression and regulation
F Verrecchia et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2002)
TGF-beta 1 is an autocrine mediator of renal tubular epithelial cell growth and collagen IV production
JP Grande et al.
EXPERIMENTAL BIOLOGY AND MEDICINE (2002)
Transforming growth factor-β repression of matrix metalloproteinase-1 in dermal fibroblasts involves Smad3
WH Yuan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
SET-related cell division autoantigen-1 (CDA1) arrests cell growth
ZL Chai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Quantification of TGF-β1 mRNA along rat nephron in obstructive nephropathy
K Fukuda et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2001)
Peroxisome proliferator-activated receptor γ-mediated transcriptional up-regulation of the hepatocyte growth factor gene promoter via a novel composite cis-acting element
JG Jiang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Functional characterization of transforming growth factor β signaling in Smad2-and Smad3-deficient fibroblasts
E Piek et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Smad3/AP-1 interactions control transcriptional responses to TGF-β in a promoter-specific manner
F Verrecchia et al.
ONCOGENE (2001)
Hepatocyte growth factor: Renotropic role and potential therapeutics for renal diseases
K Matsumoto et al.
KIDNEY INTERNATIONAL (2001)
Identification of novel TGF-β/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach
F Verrecchia et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Smurf1 interacts with transforming growth factor-β type I receptor through Smad7 and induces receptor degradation
T Ebisawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Renal insufficiency as a predictor of cardiovascular outcomes and the impact of ramipril: The HOPE randomized trial
JFE Mann et al.
ANNALS OF INTERNAL MEDICINE (2001)
Identification of differentially expressed nucleolar TGF-β1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily
LL Ozbun et al.
GENOMICS (2001)
Abnormal angiogenesis but intact hematopoietic potential in TGF-β type I receptor-deficient mice
J Larsson et al.
EMBO JOURNAL (2001)
Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy
S Mizuno et al.
KIDNEY INTERNATIONAL (2001)
High-normal serum creatinine concentration is a predictor of cardiovascular risk in essential hypertension
G Schillaci et al.
ARCHIVES OF INTERNAL MEDICINE (2001)
Endoglin expression in human and rat mesangial cells and its upregulation by TGF-β1
A Rodríguez-Barbero et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Effect of losartan on TGF-beta 1 and urinary albumin excretion in patients with type 2 diabetes mellitus and microalbuminuria
E Esmatjes et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2001)
Antibody to transforming growth factor-β ameliorates tubular apoptosis in unilateral ureteral obstruction
A Miyajima et al.
KIDNEY INTERNATIONAL (2000)
How cells read TGF-β signals
J Massagué
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2000)
Targeted mutations of transforming growth factor-β genes reveal important roles in mouse development and adult homeostasis
N Dünker et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2000)
Transforming growth factor-β1 inhibition of macrophage activation is mediated via Smad3
F Werner et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Hepatocyte growth factor predicts survival and relates to inflammation and intima media thickness in end-stage renal disease
LS Malatino et al.
AMERICAN JOURNAL OF KIDNEY DISEASES (2000)
Endogenous hepatocyte growth factor ameliorates chronic renal injury by activating matrix degradation pathways
YH Liu et al.
KIDNEY INTERNATIONAL (2000)
Transforming growth factor-β1 antisense oligodeoxynucleotides block interstitial fibrosis in unilateral ureteral obstruction
Y Isaka et al.
KIDNEY INTERNATIONAL (2000)
Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-β antibody in db/db diabetic mice
FN Ziyadeh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury
F Terzi et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction
KA Hruska et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2000)
Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor β
G von Gersdorff et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Establishment of the anti-klotho monoclonal antibodies and detection of klotho protein in kidneys
Y Kato et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes
D Koya et al.
FASEB JOURNAL (2000)
Activation of transforming growth factor-beta(1) in diabetic kidney disease
B Hellmich et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2000)