Journal
CLINICAL RESPIRATORY JOURNAL
Volume 13, Issue 4, Pages 222-231Publisher
WILEY
DOI: 10.1111/crj.13002
Keywords
central hemodynamics; exercise; lung diseases; noninvasive techniques; thoracic impedance
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Funding
- ERS/EU RESPIRE2 Marie Sklodowska-Curie Postdoctoral Research Fellowship [MCF (8465)-2015]
- FWO-Flanders [12U5618N]
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Introduction Impedance cardiography (IC) derived from morphological analysis of the thoracic impedance signal is now commonly used for noninvasive assessment of cardiac output (CO) at rest and during exercise. However, in Chronic Obstructive Pulmonary Disease (COPD), conflicting findings put its accuracy into question. Objectives We therefore compared concurrent CO measurements captured by IC (PhysioFlow: COIC) and by the indocyanine green dye dilution method (CODD) in patients with COPD. Methods Fifty paired CO measurements were concurrently obtained using the two methods from 10 patients (FEV1: 50.5 +/- 17.5% predicted) at rest and during cycling at 25%, 50%, 75% and 100% peak work rate. Results From rest to peak exercise COIC and CODD were strongly correlated (r = 0.986, P < 0.001). The mean absolute and percentage differences between COIC and CODD were 1.08 L/min (limits of agreement (LoA): 0.05-2.11 L/min) and 18 +/- 2%, respectively, with IC yielding systematically higher values. Bland-Altman analysis indicated that during exercise only 7 of the 50 paired measurements differed by more than 20%. When data were expressed as changes from rest, correlations and agreement between the two methods remained strong over the entire exercise range (r = 0.974, P < 0.001, with no significant difference: 0.19 L/min; LoA: -0.76 to 1.15 L/min). Oxygen uptake (VO2) and CODD were linearly related: r = 0.893 (P < 0.001), CODD = 5.94 x VO2 + 2.27 L/min. Similar results were obtained for VO2 and COIC (r = 0.885, P < 0.001, COIC = 6.00 x VO2 + 3.30 L/min). Conclusions These findings suggest that IC provides an acceptable CO measurement from rest to peak cycling exercise in patients with COPD.
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