Journal
CLINICAL INFECTIOUS DISEASES
Volume 69, Issue 11, Pages 2022-2025Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciz250
Keywords
Kaposi sarcoma; Kaposi sarcoma herpesvirus; human herpesvirus 8; Kaposi sarcoma herpesvirus inflammatory cytokine syndrome; pediatric oncology
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Funding
- National Cancer Institute at the NIH [R21CA217137]
- Baylor-University of Texas Houston Center for AIDS Research through National Institute of Allergy and Infectious Diseases [AI36211, CA019014, CA190152, CA192744]
- United States Agency for International Development through the Tingathe Program [674-A-00-10-00093-00]
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We describe 7 human immunodeficiency virus-infected Malawian children with Kaposi sarcoma who met criteria for Kaposi sarcoma herpesvirus (KSHV) inflammatory cytokine syndrome. Each presented with persistent fevers, bulky lymphadenopathy, massive hepatosplenomegaly, and severe cytopenias. Plasma analyses were performed in 2 patients, both demonstrating extreme elevations of KSHV viral load and interleukin 6.
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