Journal
CLINICAL INFECTIOUS DISEASES
Volume 68, Issue 11, Pages 1938-1941Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciy942
Keywords
epidermodysplasia verruciformis; immunodeficiency; ITK; human papillomavirus; EBV infection
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Funding
- Department of Dermatology and Cutaneous Biology of Thomas Jefferson University
- National Institute of Health [R21 AI107508-02]
- Rockefeller University
- Institut National de la Sante et de la Recherche Medicale, Paris Descartes University
- St. Giles Foundation
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Biallelic mutations in the ITK gene cause a T-cell primary immunodeficiency with Epstein-Barr virus (EBV)-lymphoproliferative disorders. We describe a novel association of a homozygous ITK mutation with -human papillomavirus (HPV)-positive epidermodysplasia verruciformis. Thus, loss of function in ITK can result in broad dysregulation of T-cell responses to oncogenic viruses, including -HPV and EBV.
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