Journal
CLINICAL INFECTIOUS DISEASES
Volume 69, Issue 8, Pages 1436-1439Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciz134
Keywords
malaria; infectiousness; anopheles; transmission; treatment
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Funding
- Bill & Melinda Gates Foundation [INDIE OPP1173572]
- European Research Council [ERC-2014-StG639776]
- MRC [MR/R015600/1, MR/R010161/1] Funding Source: UKRI
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Gametocyte density and sex ratio can predict the proportion of mosquitoes that will become infected after feeding on blood of patients receiving nongametocytocidal drugs. Because primaquine and methylene blue sterilize gametocytes before affecting their density and sex ratio, mosquito feeding experiments are required to demonstrate their early transmission-blocking effects.
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