Journal
CLINICAL ENDOCRINOLOGY
Volume 90, Issue 6, Pages 814-821Publisher
WILEY
DOI: 10.1111/cen.13954
Keywords
birthweight; gestational diabetes; gestational hypertension; large for gestational age; lifestyle; polycystic ovary syndrome; preterm birth
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Funding
- Premier's Science and Research Fund, South Australian Government
- New Enterprise Research Fund, Foundation for Research Science and Technology
- Health Research Council [04/198]
- Evelyn Bond Fund, Auckland District Health Board Charitable Trust
- Health Research Board of Ireland [CSA/2007/2]
- National Health Service NEAT Grant [FSD025]
- Biotechnology and Biological Sciences Research Council [GT084]
- University of Manchester Proof of Concept Funding (University of Manchester)
- Guy's and St. Thomas' Charity (King's College London)
- Tommy's charity
- Cerebra UK
- SACVRDP Fellowship
- National Heart Foundation
- South Australian Department of Health
- South Australian Health and Medical Research Institute [AC11S374]
- National Heart Foundation Future Leader Fellowship [101169]
- Science Foundation Ireland Program Grant for INFANT [12/RC/2272]
- Lloyd Cox Professorial Research Fellowship from the University of Adelaide
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Objectives To investigate the risk of pregnancy complications in women with and without polycystic ovary syndrome after consideration of lifestyle factors. Design Prospective cohort. Patients and measurements Participants (n = 5628) were apparently healthy nulliparous women with singleton pregnancies from the Screening for Pregnancy Endpoints study in New Zealand, Australia, United Kingdom and Ireland. Multivariable regression models were performed assessing the association of self-reported polycystic ovary syndrome status with pregnancy complications with consideration of lifestyle factors at the 15th week of gestation. Results Women with polycystic ovary syndrome (n = 354) were older, had a higher socio-economic index and body mass index and were less likely to consume alcohol and smoke but more likely to do vigorous exercise and take multivitamins. In univariable analysis, polycystic ovary syndrome was associated with increased risk of gestational diabetes (OR: 2.2, 95% CI: 1.2, 4.0). In multivariable models, polycystic ovary syndrome was only significantly associated with decreased risk of large for gestational age (OR: 0.62, 95% CI: 0.40, 0.98) with a population attributable risk of 0.22%. None of the other outcomes were attributable to polycystic ovary syndrome status. Conclusions Polycystic ovary syndrome is associated with a lower risk of large for gestational age infants. In this low-risk population, the risk of pregnancy complications was not increased in women with polycystic ovary syndrome who were following a healthy lifestyle. Further studies are warranted assessing the contribution of lifestyle factors to the risk of pregnancy complications in higher risk groups of women with and without polycystic ovary syndrome.
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