Journal
CLINICA CHIMICA ACTA
Volume 490, Issue -, Pages 17-27Publisher
ELSEVIER
DOI: 10.1016/j.cca.2018.12.013
Keywords
LncRNAs; Ovarian cancer; Proliferation; Apoptosis; Metastasis; Diagnosis
Categories
Funding
- National Natural Science Foundation of China [81602551, 81702613]
- Key Research Program for the Social Development of Jiangsu Province, China [BE2015718]
- National Program on Key Research Project [2016YFC0905900]
- Medical Training Programme Foundation for the Talents by Jiangsu Provincial Department of Health [17 [2016]]
- 333 Talent Project of Jiangsu Province, top-level [4 [2016]]
- National Key Clinical Specialist Construction Programs of China [544 [2013]]
- Major Program of the Natural Science Foundation of Jiangsu Province [BL2014090]
- Natural Science Foundation of Jiangsu Province [BK20151579]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) [JX10231802]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [SJCX17_0387]
- young talents program of Jiangsu Cancer Hospital [2017YQL-10]
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Ovarian cancer is one of the most common gynecologic malignancies and has a poor prognosis. Recently, long noncoding RNAs (lncRNAs) have been identified as key regulators of cancer development. Studies have shown that the dysregulation of lncRNAs is frequently observed in ovarian cancer and greatly contributes to malignant phenotypical changes. In this review, we provide perspectives on the involvement of lncRNAs in the proliferation, apoptosis, cell cycle, migration, invasion, metastasis and drug resistance of ovarian cancer based on recent discoveries. Then, we discuss the role of lncRNAs in predicting the prognosis of ovarian cancer. Finally, we provide insight into the potential of lncRNAs for evaluating the diagnosis and prognosis of ovarian cancer.
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