Journal
CHIMIA
Volume 73, Issue 1-2, Pages 81-85Publisher
SWISS CHEMICAL SOC
DOI: 10.2533/chimia.2019.81
Keywords
ECM; Hydrogel; Matrigel (TM); Organoid; Photo-patterning; Synthetic gel; Self-healing
Categories
Funding
- National Center of Competence in Research (NCCR) Bio-Inspired Materials
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Organoids have stepped into the limelight as unique in vitro systems for modeling organ development, function and disease. This review provides a perspective on how chemically defined, bio-inspired hydrogels could be used for replacing ill-defined matrices derived from the native extracellular matrix (ECM) that are used for generating organoids in 3D stem cell culture. In particular, we propose the use of self-healing and light-responsive matrices that should afford control over the inherently stochastic self-organization process that currently underlies organoid morphogenesis. Such designer ECMs could accelerate the translation of organoid technology from the laboratory into various real-life applications.
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