Journal
CHEMOSPHERE
Volume 216, Issue -, Pages 437-448Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2018.10.123
Keywords
Advanced wastewater treatment; Trace organic compound; Organic micropollutant; QSAR; Hydroxyl radicals
Categories
Ask authors/readers for more resources
The pharmaceutical valsartan is classified as a trace organic compound and is released into wastewater from human consumption. Trace organic compounds are not completely removed during conventional wastewater treatment. In order to prevent their release into the aquatic environment, advanced wastewater treatment technologies such as ozonation are currently implemented. Ozonation leads to the formation of transformation products (TPs), which then enter the receiving waters. In the present work, laboratory-scale ozonation experiments of valsartan solutions were performed. The resulting TPs were analyzed by HPLC-MS and searched for using a non-targeted approach. Of the 51 compounds detected, 27 have tentative structural suggestions based on MS/MS experiments. Ozonation of valsartan does not lead to the formation of TPs with higher toxicity towards A. fischeri than the parent compound. According to QSAR-based environmental behavior estimations, most TPs reveal lower lipophilicity, increased biodegradability as well as decreased acute and chronic toxicities concerning fish, daphnia and algae compared to their parent compound valsartan. (C) 2018 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available