Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 14, Issue 9, Pages 1436-1442Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201900306
Keywords
anticancer; indazolones; metal-free; photocatalyst-free; synthetic methods
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Funding
- Natural Science Foundation of China [21676076, 21725602, 21878071]
- Hu-Xiang High Talent of Hunan Province [2018RS3042]
- Recruitment Program for Foreign Experts of China [WQ20164300353]
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A convenient photocatalyst-free method for the synthesis of redox-active 1,2-dihydro-3H-indazol-3-one derivatives from (2-nitroaryl)methanol and amines was developed. The reaction proceeded efficiently at room temperature by irradiation of UV light under CO2 atmosphere (1.0atm, flow) without any photocatalysts or additives. This mild, operationally simple method shows wide functional tolerance. The carbamate formed in situ from CO2 and amine is proposed to be the key of this reaction. Some of these compounds synthesized by the present method were found to exhibit high anticancer activities, which can lower the viability of cancerous cell lines such as HeLa, MCF-7 and U87.
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