Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 14, Issue 4, Pages 509-526Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201801437
Keywords
functional imaging; intracellular targeting; photodynamic therapy; Zinc-complexes
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Funding
- National Natural Science Foundation of China [21602003]
- Anhui Provincial Natural Science Foundation of China [1708085MC68]
- Anhui University Doctor Startup Fund [J01001962]
- Anhui Distinguished Foreign Expert Programme
- EPSRC [EP/K005030/1, EP/N026322/1] Funding Source: UKRI
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Zinc is a biocompatible element that exists as the second most abundant transition metal ion and an indispensable trace element in the human body. Compared to traditional metal-organic complexes systems, d(10) metal Zn-II complexes not only exhibit a large Stokes shift and good photon stability but also possess strong emission and low cytotoxicity with a relatively small molecular weight. The use of Zn-II complexes has emerged in the last decade as a versatile and convenient tool for numerous biological applications, including bioimaging, molecular and protein recognition, as well as photodynamic therapy. Herein, we review recent developments involving Zn-II metal complexes applied as specific subcellular compartment imaging probes and their correlated utilizations.
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