Journal
CHEMICO-BIOLOGICAL INTERACTIONS
Volume 301, Issue -, Pages 6-25Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2018.11.020
Keywords
Linear dose response; Single-hit; LNT; Dose response; Cancer risk assessment; Mutation, ionizing radiation
Funding
- U.S. Air Force [AFOSR FA9550-13-1-0047]
- ExxonMobil Foundation [S18200000000256]
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The linear no-threshold (LNT) single-hit (SH) dose response model for cancer risk assessment is comprehensively assessed with respect to its historical foundations. This paper also examines how mistakes, ideological biases, and scientific misconduct by key scientists affected the acceptance, validity, and applications of the LNT model for cancer risk assessment. In addition, the analysis demonstrates that the LNT single-hit model was inappropriately adopted for governmental risk assessment, regulatory policy, practices, and for risk communication.
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