Journal
CHEMICAL RESEARCH IN TOXICOLOGY
Volume 32, Issue 3, Pages 348-361Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrestox.9b00036
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Enzymatic one-electron reduction of heterocyclic N-oxides can lead to the intracellular generation of reactive oxygen species via several different chemical pathways. These reactions may be relevant to hypoxia-selective anticancer drugs, antimicrobial agents, and unwanted toxicity of heterocylic nitrogen compounds.
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