Journal
CHEMBIOCHEM
Volume 20, Issue 13, Pages 1615-1627Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201800810
Keywords
bioorthogonal chemistry; cleavage reactions; cycloaddition; drug delivery; protecting groups
Funding
- University of Utah
- Huntsman Cancer Institute
- Utah Science and Technology Research (USTAR) Initiative
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Bioorthogonal reactions that proceed readily under physiological conditions without interference from biomolecules have found widespread application in the life sciences. Complementary to the bioorthogonal reactions that ligate two molecules, reactions that release a molecule or cleave a linker are increasingly attracting interest. Such dissociative bioorthogonal reactions have a broad spectrum of uses, for example, in controlling bio-macromolecule activity, in drug delivery, and in diagnostic assays. This review article summarizes the developed bioorthogonal reactions linked to a release step, outlines representative areas of the applications of such reactions, and discusses aspects that require further improvement.
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