Journal
CELL STRESS & CHAPERONES
Volume 24, Issue 2, Pages 469-473Publisher
SPRINGER
DOI: 10.1007/s12192-019-00978-0
Keywords
Heat shock response; Thyroxine; Heat shock proteins; Yeast; Thermotolerance
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Funding
- National and Kapodistrian University of Athens Research Account, Greece [5900]
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The cellular stress response (CSR) is a universal inducible reaction modulated, among others, by heat, drugs, and hormones. We aimed to investigate the role of l-thyroxine (T4) on the heat shock (HS) response in Saccharomyces cerevisiae. The CSR was evaluated by determining growth and viability of post-logarithmic phase grown yeast cultures after HS at 53 degrees C for 30min. We found that long-term T4 exposure can induce a dose-dependent and Hsp90 and H+ trafficking-related thermotolerance in yeast.
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