Journal
CELL STEM CELL
Volume 24, Issue 2, Pages 213-225Publisher
CELL PRESS
DOI: 10.1016/j.stem.2019.01.001
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Funding
- Glenn Foundation for Aging Research
- NIH [P01 AG036695, TR01 AG047820, R01 AR073248, AG023806]
- Department of Veterans Affairs (BLRD)
- Department of Veterans Affairs (RRD)
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Stem cells can reside in a state of reversible growth arrest, or quiescence, for prolonged periods of time. Although quiescence has long been viewed as a dormant, low-activity state, increasing evidence suggests that quiescence represents states of poised potential and active restraint, as stem cells idle'' in anticipation of activation, proliferation, and differentiation. Improved understanding of quiescent stem cell dynamics is leading to novel approaches to enhance maintenance and repair of aged or diseased tissues. In this Review, we discuss recent advances in our understanding of stem cell quiescence and techniques enabling more refined analyses of quiescence in vivo.
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