Journal
CELL DEATH AND DIFFERENTIATION
Volume 26, Issue 11, Pages 2314-2328Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41418-019-0302-0
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Funding
- National Natural Science Foundation of China [31870862, 81773256, 81572982, 81372442, 81172164]
- National Key Basic Research Program of China [2014CB910800, 2015CB859800, 2013CB910301]
- Sci-Tech Key Program of the Guangdong Province Science Foundation [2014A020212066]
- Science and Technology Planning Project of Guangzhou, China [201804010385, 201605030012]
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Stimulator of interferon genes (STING), a major adaptor protein in antiviral innate immune signaling, is considered as one of the most important regulators of antiviral and antitumor immunity. Although STING agonists are now intensively studied in clinical trials as a new class of adjuvants to boost cancer immunotherapy, the tumor-intrinsic role of the STING pathway in shaping the tumor microenvironment remains controversial. Here, we discovered that STING plays a vital role in regulation of myeloid-derived suppressor cell (MDSC) differentiation and antitumor immunity in Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC). Mechanistic analyses reveal that STING represses NPC-derived MDSC induction by enhancing SOCS1 expression in both tumor cells and MDSCs. SOCS1 physically interacts with STAT3 through its SH2 domain to prevent STAT3 phosphorylation and dimerization, resulting in reduced MDSC induction via inhibition of GM-CSF and IL-6 production. Notably, reduced tumoral STING expression was found to be significantly associated with a poor prognosis for NPC patients. Our findings reveal a novel mechanism linking STING to tumor microenvironmental cytokine production and MDSC induction.
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