Journal
CELL CYCLE
Volume 18, Issue 8, Pages 795-808Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2019.1591125
Keywords
Cell cycle; in silico simulation; agent-based modeling; synchronization
Categories
Funding
- Region Midi-Pyrenees
- Universite Toulouse Capitole
- CNRS
- University of Toulouse III
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Modeling and in silico simulations are of major conceptual and applicative interest in studying the cell cycle and proliferation in eukaryotic cells. In this paper, we present a cell cycle checkpoint-oriented simulator that uses agent-based simulation modeling to reproduce the dynamics of a cancer cell population in exponential growth. Our in silico simulations were successfully validated by experimental in vitro supporting data obtained with HCT116 colon cancer cells. We demonstrated that this model can simulate cell confluence and the associated elongation of the G1 phase. Using nocodazole to synchronize cancer cells at mitosis, we confirmed the model predictivity and provided evidence of an additional and unexpected effect of nocodazole on the overall cell cycle progression. We anticipate that this cell cycle simulator will be a potential source of new insights and research perspectives.
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