Journal
CARDIOVASCULAR RESEARCH
Volume 115, Issue 5, Pages 844-853Publisher
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvz035
Keywords
Cardio-oncology; Heart failure; Risk factors; Cardiovascular risk factors; Hypertension; Lipids; Biomarkers; Inflammation
Categories
Funding
- Netherlands Heart Foundation (CVON DOSIS) [2014-40]
- Netherlands Heart Foundation (CVON SHE-PREDICTS-HF) [2017-21]
- Netherlands Heart Foundation (CVON RED-CVD) [2017-11]
- Innovational Research Incentives Scheme programme of the Netherlands Organization for Scientific Research (NWO VIDI) [917.13.350]
- European Research Council [ERC CoG 818715]
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Cardiovascular (CV) disease and cancer are the leading causes of death.(1,2) Over the last decades, it has been appreciated that both CV disease and cancer are more common in individuals in whom risk factors for disease development accumulate, and preventative measures have been extremely important in driving down the incidence of disease.(3-6) In general, the field of epidemiology, risk reduction, and preventative trials is divided into health care professionals who have an interest in either CV disease or cancer. As a result, the medical literature and medical practice has largely focused on the one disease, or the other. However, human individuals do not behave according to this dogma. Emerging data clearly suggest that identical risk factors may lead to CV disease in the one individual, but may cause cancer in another, or even both diseases in the same individual. This overlap exists between risk factors that are historically classified as CV risk factors' as these factors do equally strong predict cancer development. Therefore, we propose that a holistic approach might better estimate actual risks for CV disease and cancer. In this review, we summarize current insights in common behavioural risk factors for heart failure, being the most progressed and lethal form of CV disease, and cancer.
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