Journal
CARBOHYDRATE POLYMERS
Volume 208, Issue -, Pages 86-96Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.12.060
Keywords
Sulfated polysaccharide; Sphere-like chain conformation; Ester sulfate; Anti-leukemia; Antiangiogenic activity
Categories
Funding
- Major Program of National Natural Science Foundation of China [21334005]
- Major International Joint Research Project [21620102004]
- National Natural Science Foundation of China [21574102, 21274114]
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A fucoidan derived from marine brown algae has great potential in biomedical filed. Herein, the fucoidan was successfully isolated and purified by using chitosan microspheres, resulting in the sulfate fucoidan (CF) with degree of sulfation (DS) of 0.94. CF was identified to be highly branched, consisting of fucose (77.4%) and galactose (13.9%), etc., supported by the results of GC-MS and light scattering with the structure-sensitive parameter of 0.98 in 0.15 M aqueous NaNO3. The individual CF and its desulfated derivative chains adopted sphere-like conformation in water, observed by atomic force microscopy. CF exhibited higher antiangiogenesis than the desulfated one and strong antileukemia activities through inhibiting cell proliferation and inducing cell apoptosis via cell cycle arrest at G1 phase in vitro. This work provided important information that ester sulfate groups of polysaccharide played an important role in the enhancing of bioactivities of fucoidan, and put forward to a potential drug to treat acute myelocytic leukemia (AML) and tumors.
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