Journal
CARBOHYDRATE POLYMERS
Volume 206, Issue -, Pages 362-370Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.11.014
Keywords
Smart wound dressing; kappa-carrageenan; Locust bean gum; Cranberry; Anthocyanins; pH sensor
Categories
Funding
- Fundacao de Amparo a Pesquisa e Inovacao do Estado de Santa Catarina (FAPESC)
- Secretaria de Desenvolvimento Economico, Ciencia e Tecnologia do RS (SDECT) - Programa de Apoio aos Polos Tecnologicos do RS -
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [300927/2015-0]
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A smart wound dressing based on carrageenan (kappa C), locust bean gum (LBG), and cranberry extract (CB) for monitoring bacterial wound infections was developed and characterized using UV-vis spectroscopy, FT-IR, and SEM. The mechanical, swelling, cytotoxic and pH sensor properties were also investigated. UV-vis spectra demonstrated that the obtained kappa C:LBG:CB hydrogel film exhibited a visible change of colors as it was immersed in PBS solution pH 5.0, 7.3 and 9.0. The spectra of FT-IR suggested that chemical interactions had occurred between kappa C and CB extract. The obtained kappa C:LBG:CB hydrogel film exhibited adequate mechanical properties and a swelling behavior dependent on pH. Cytotoxicity tests indicated that kappa C:LBG:CB hydrogel film had dose-dependent cytotoxicity against NIH 3T3 fibroblast cells. The in vitro studies using Staphylococcus aureus and Pseudomonas aeruginosa demonstrated that the color changes of the kappa C:LBG:CB hydrogel film could be observed by naked eyes, confirming the potential use of the obtained hydrogel film as a visual system for monitoring bacterial wound infections.
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