Journal
CARBOHYDRATE POLYMERS
Volume 205, Issue -, Pages 533-539Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.10.095
Keywords
Biofilms; Chitosan; Micelles; Essential oil; Light-controllable
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Funding
- National Natural Science Foundation of China [NSFC 31700707]
- Scientific Research Fund of Northwest AF University [Z109021636]
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Bacterial biofilms are widely associated with persistent infections and food contamination. High resistance to conventional antimicrobial agents resulted in an urgent need for novel formulation to eliminate these bacterial communities. Herein we fabricated light controllable chitosan micelles loading with thymol (T-TCP) for elimination of biofilm. Due to the exterior chitosan, T-TCP micelles easily bind to negative biofilm through electrostatic interaction and efficiently deliver the essential oil payloads. Under irradiation, T-TCP micelles generated ROS, which triggered simultaneous thymol release and also resulted in additional ROS-inducing bactericidal effects, both effectively eradicating biofilms of Listeria monocytogenes and Staphylococcus aureus. This formulation provided a platform for other water-insoluble antimicrobials and might be used as a potent and controllable solution to biofilm fighting.
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