Journal
CANCER SCIENCE
Volume 110, Issue 4, Pages 1140-1147Publisher
WILEY
DOI: 10.1111/cas.13965
Keywords
cancer biology; delivery system; exosomes; miRNA; therapeutics
Categories
Funding
- Japan Society for the Promotion of Science [C/16K08261]
- Japan Agency for Medical Research and Development
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Over the past few decades, siRNA and miRNA have attracted a great deal of attention from researchers and clinicians. These molecules have been extensively studied from the standpoint of developing biopharmaceuticals against various diseases, including heart disease, diabetes and cancers. siRNA suppresses only a single target, whereas each miRNA regulates the expression of multiple target genes. More importantly, because miRNA are also secreted from cancer cells, and their aberrant expression is associated with tumor development and progression, they represent not only therapeutic targets but also promising biomarkers for diagnosis and prognosis. Therefore, miRNA may be more effective tools against cancers, in which multiple signal pathways are dysregulated. In this review, we summarize recent progress in the development of miRNA therapeutics for the treatment of cancer patients, and describe delivery systems for oligonucleotide therapeutics.
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