Journal
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Volume 83, Issue 5, Pages 809-815Publisher
SPRINGER
DOI: 10.1007/s00280-019-03782-w
Keywords
Ewing's sarcoma; Patient-derived orthotopic xenograft; PDOX; Nude mouse; Regorafenib
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Funding
- Yokohama City University research grant KAMOME Project
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Purpose Ewing's sarcoma (ES) is a rare and recalcitrant disease which is in need of a development of a novel effective therapy. The aim of this study was to investigate the efficacy of regorafenib on an ES tumor in a patient-derived orthotopic xenograft (PDOX) model. Methods The ES PDOX models were established orthotopically in the right chest wall of nude mice to match the site of the tumor in the donor patient. The ES PDOX models were randomized into three groups (G) when the tumor volume reached 75 mm(3): G1: untreated control; G2: doxorubicin (DOX) (i.p., 3 mg/kg, weekly, 2 weeks); G3: regorafenib (REG) (p.o., 30 mg/kg, daily, 2 weeks). Tumor volume and body weight were measured twice a week. All mice were sacrificed on day 15. Results DOX was ineffective compared to the control group (P = 0.229). REG regressed the tumor size (P < 0.001 and P < 0.001, relative to control and DOX, respectively). Conclusions Our findings suggest that REG has clinical potential for ES patients whose tumors respond to REG in a PDOX model.
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