4.5 Review

Causes, consequences, and therapy of tumors acidosis

Related references

Note: Only part of the references are listed.
Review Oncology

Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH

Annasofia Anemone et al.

CANCER AND METASTASIS REVIEWS (2019)

Review Biochemistry & Molecular Biology

Recent Development of pH-Responsive Polymers for Cancer Nanomedicine

Houliang Tang et al.

MOLECULES (2019)

Review Cell Biology

Antibody-drug conjugates: recent advances in conjugation and linker chemistries

Kyoji Tsuchikama et al.

PROTEIN & CELL (2018)

Correction Biotechnology & Applied Microbiology

Applications of pHLIP Technology for Cancer Imaging and Therapy (vol 35, pg 653, 2017)

Linden C. Wyatt et al.

TRENDS IN BIOTECHNOLOGY (2018)

Article Biochemistry & Molecular Biology

Identification of a Unique Inhibitor-Binding Site on Choline Kinase α

Stefanie L. Kall et al.

BIOCHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

Zandra E. Walton et al.

Review Medicine, Research & Experimental

Antibody-Drug Conjugates for Cancer Treatment

John M. Lambert et al.

ANNUAL REVIEW OF MEDICINE, VOL 69 (2018)

Article Multidisciplinary Sciences

Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors

Linden C. Wyatt et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Oncology

Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

Shen-Han Lee et al.

BRITISH JOURNAL OF CANCER (2018)

Article Multidisciplinary Sciences

Systems analysis of intracellular pH vulnerabilities for cancer therapy

Erez Persi et al.

NATURE COMMUNICATIONS (2018)

Review Pharmacology & Pharmacy

Carbonic anhydrase inhibitors as emerging agents for the treatment and imaging of hypoxic tumors

Claudiu T. Supuran

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2018)

Article Nanoscience & Nanotechnology

Decoration of Nanovesicles with pH (Low) Insertion Peptide (pHLIP) for Targeted Delivery

Federica Rinaldi et al.

NANOSCALE RESEARCH LETTERS (2018)

Article Urology & Nephrology

Randomized, Controlled Trial of TRC101 to Increase Serum Bicarbonate in Patients with CKD

David A. Bushinsky et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

Review Oncology

Cancer metabolism: a therapeutic perspective

Ubaldo E. Martinez-Outschoorn et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

Article Oncology

Hypoxia, pseudohypoxia and cellular differentiation

Sofie Mohlin et al.

EXPERIMENTAL CELL RESEARCH (2017)

Article Genetics & Heredity

Carbonic anhydrase IX inhibition affects viability of cancer cells adapted to extracellular acidosis

Elena Andreucci et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2017)

Review Biotechnology & Applied Microbiology

Applications of pHLIP Technology for Cancer Imaging and Therapy

Linden C. Wyatt et al.

TRENDS IN BIOTECHNOLOGY (2017)

Article Multidisciplinary Sciences

An update on anticancer drug development and delivery targeting carbonic anhydrase IX

Justina Kazokaite et al.

PEERJ (2017)

Review Oncology

Cancer nanomedicine: progress, challenges and opportunities

Jinjun Shi et al.

NATURE REVIEWS CANCER (2017)

Article Biochemistry & Molecular Biology

Lactate Metabolism in Human Lung Tumors

Brandon Faubert et al.

Review Biochemistry & Molecular Biology

Carbonic Anhydrase Inhibition and the Management of Hypoxic Tumors

Claudiu T. Supuran

METABOLITES (2017)

Article Public, Environmental & Occupational Health

Micronized palmitoylethanolamide/trans-polydatin treatment of endometriosis-related pain: a meta-analysis

Ugo Indraccolo et al.

ANNALI DELL ISTITUTO SUPERIORE DI SANITA (2017)

Review Medicine, Research & Experimental

Antibody-Drug Conjugates (ADCs) for Personalized Treatment of Solid Tumors: A Review

John M. Lambert et al.

ADVANCES IN THERAPY (2017)

Article Oncology

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

Shari Pilon-Thomas et al.

CANCER RESEARCH (2016)

Review Genetics & Heredity

Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters

Ibtissam Marchiq et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2016)

Article Biochemistry & Molecular Biology

The Structure of Carbonic Anhydrase IX Is Adapted for Low-pH Catalysis

Brian P. Mahon et al.

BIOCHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Na+/H+ antiporter (NHE1) and lactate/H+ symporters (MCTs) in pH homeostasis and cancer metabolism

Laurent Counillon et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

Article Gastroenterology & Hepatology

High-doses of proton pump inhibitors in refractory gastro-intestinal cancer: A case series and the state of art

Rosa Falcone et al.

DIGESTIVE AND LIVER DISEASE (2016)

News Item Biotechnology & Applied Microbiology

Cancer metabolism pipeline breaks new ground

Asher Mullard

NATURE REVIEWS DRUG DISCOVERY (2016)

Article Multidisciplinary Sciences

Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats

Geraldine Harriman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Nanoscience & Nanotechnology

Photosensitizer-Loaded pH-Responsive Hollow Gold Nanospheres for Single Light-Induced Photothermal/Photodynamic Therapy

Meng Yu et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

Article Biochemistry & Molecular Biology

Low pH increases the yield of exosome isolation

Jae-Jun Ban et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Biochemistry & Molecular Biology

Anticancer activity of koningic acid and semisynthetic derivatives

Nicolas J. Rahier et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2015)

Review Chemistry, Medicinal

Carbonic anhydrase IX inhibitors in cancer therapy: an update

Claudiu T. Supuran et al.

FUTURE MEDICINAL CHEMISTRY (2015)

Review Oncology

Proton pump inhibitors for the treatment of cancer in companion animals

Megan Walsh et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2015)

Article Oncology

Intermittent high dose proton pump inhibitor enhances the antitumor effects of chemotherapy in metastatic breast cancer

Bi-Yun Wang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2015)

Article Chemistry, Medicinal

Evaluation of Acid Tolerance of Drugs Using Rats and Dogs Controlled for Gastric Acid Secretion

Yohei Kosugi et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2015)

Article Medicine, Research & Experimental

Inhibition of Cancer Cell Proliferation and Breast Tumor Targeting of pHLIP-Monomethyl Auristatin E Conjugates

Kelly E. Burns et al.

MOLECULAR PHARMACEUTICS (2015)

Review Chemistry, Multidisciplinary

Current ADC Linker Chemistry

Nareshkumar Jain et al.

PHARMACEUTICAL RESEARCH (2015)

Article Multidisciplinary Sciences

Enhancement of radiation effect on cancer cells by gold-pHLIP

Michael P. Antosh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane

Mehdi Damaghi et al.

NATURE COMMUNICATIONS (2015)

Article Oncology

Vascular measurements correlate with estrogen receptor status

Mark C. Lloyd et al.

BMC CANCER (2014)

Article Oncology

Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer

Radoslaw Polanski et al.

CLINICAL CANCER RESEARCH (2014)

Article Medicine, Research & Experimental

High dose lansoprazole combined with metronomic chemotherapy: a phase I/II study in companion animals with spontaneously occurring tumors

Enrico P. Spugnini et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2014)

Review Biology

The chemistry, physiology and pathology of pH in cancer

Pawel Swietach et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2014)

Article Oncology

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

Veronica Estrella et al.

CANCER RESEARCH (2013)

Review Biochemistry & Molecular Biology

Inside Out: Targeting NHE1 as an Intracellular and Extracellular Regulator of Cancer Progression

Joseph J. Provost et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2013)

Article Chemistry, Multidisciplinary

Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation

Lourdes Castaneda et al.

CHEMICAL COMMUNICATIONS (2013)

Article Cell Biology

Stimulus-responsive nanopreparations for tumor targeting

Lin Zhu et al.

INTEGRATIVE BIOLOGY (2013)

Article Medicine, Research & Experimental

Proton pump inhibitor chemosensitization in human osteosarcoma: from the bench to the patients' bed

Stefano Ferrari et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2013)

Article Multidisciplinary Sciences

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

Cosimo Commisso et al.

NATURE (2013)

Review Plant Sciences

Polydatin: A review of pharmacology and pharmacokinetics

Qiao-Hui Du et al.

PHARMACEUTICAL BIOLOGY (2013)

Article Cell Biology

Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-13C]Pyruvate

Sarah J. Nelson et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Article Oncology

Acid-Mediated Tumor Proteolysis: Contribution of Cysteine Cathepsins

Jennifer M. Rothberg et al.

NEOPLASIA (2013)

Review Oncology

Tumor microenvironment and nanotherapeutics

Meenakshi Upreti et al.

TRANSLATIONAL CANCER RESEARCH (2013)

Article Oncology

Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments

Jonathan W. Wojtkowiak et al.

CANCER RESEARCH (2012)

Review Pharmacology & Pharmacy

A Rationale for the Use of Proton Pump Inhibitors as Antineoplastic Agents

Angelo De Milito et al.

CURRENT PHARMACEUTICAL DESIGN (2012)

Review Pharmacology & Pharmacy

Targeting cancer metabolism - aiming at a tumour's sweet-spot

Neil P. Jones et al.

DRUG DISCOVERY TODAY (2012)

Article Gastroenterology & Hepatology

Solitary Necrotic Nodules of the Liver: Histology and Diagnosis With CT and MRI

Li Xia Wang et al.

HEPATITIS MONTHLY (2012)

Article Dentistry, Oral Surgery & Medicine

Blocking the Na+/H+ exchanger 1 with cariporide (HOE642) reduces the hypoxia-induced invasion of human tongue squamous cell carcinoma

C. Lv et al.

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2012)

Review Biochemistry & Molecular Biology

The monocarboxylate transporter familyuStructure and functional characterization

Andrew P. Halestrap

IUBMB LIFE (2012)

Review Biochemistry & Molecular Biology

The monocarboxylate transporter familyuRole and regulation

Andrew P. Halestrap et al.

IUBMB LIFE (2012)

Review Biophysics

Role of monocarboxylate transporters in human cancers: state of the art

Celine Pinheiro et al.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2012)

Article Urology & Nephrology

Systemic Buffers Inhibit Carcinogenesis in TRAMP Mice

Arig Ibrahim-Hashim et al.

JOURNAL OF UROLOGY (2012)

Review Oncology

Evolutionary dynamics of carcinogenesis and why targeted therapy does not work

Robert J. Gillies et al.

NATURE REVIEWS CANCER (2012)

Article Oncology

Reduction of metastasis using a non-volatile buffer

Arig Ibrahim Hashim et al.

CLINICAL & EXPERIMENTAL METASTASIS (2011)

Article Medicine, Research & Experimental

Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors

Enrico P. Spugnini et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2011)

Review Biotechnology & Applied Microbiology

Interfering with pH regulation in tumours as a therapeutic strategy

Dario Neri et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

Review Biophysics

Imaging pH and metastasis

Arig Ibrahim Hashim et al.

NMR IN BIOMEDICINE (2011)

Review Biophysics

MR-visible lipids and the tumor microenvironment

E. James Delikatny et al.

NMR IN BIOMEDICINE (2011)

Article Multidisciplinary Sciences

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

Renaud Le Floch et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Biochemistry & Molecular Biology

NHE1 promotes invadopodial ECM proteolysis through acidification of the peri-invadopodial space

Giovanni Busco et al.

FASEB JOURNAL (2010)

Review Cell Biology

Sensors and regulators of intracellular pH

Joseph R. Casey et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Article Oncology

Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases

Ian F. Robey et al.

CANCER RESEARCH (2009)

Article Biochemistry & Molecular Biology

Function of a Subunit Isoforms of the V-ATPase in pH Homeostasis and in Vitro Invasion of MDA-MB231 Human Breast Cancer Cells

Ayana Hinton et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

Isabella Parolini et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Glucose-dependent active ATP depletion by koningic acid kills high-glycolytic cells

Shohei Kumagai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Article Veterinary Sciences

Cancer incidence in pet dogs: Findings of the animal tumor registry of Genoa, Italy

D. F. Merlo et al.

JOURNAL OF VETERINARY INTERNAL MEDICINE (2008)

Article Multidisciplinary Sciences

Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane

Yana K. Reshetnyak et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Oncology

Acid-mediated tumor invasion: a multidisciplinary study

RA Gatenby et al.

CANCER RESEARCH (2006)

Article Biochemistry & Molecular Biology

The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1α-dependent mechanism

MS Ullah et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Review Oncology

The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis

RA Cardone et al.

NATURE REVIEWS CANCER (2005)

Article Urology & Nephrology

Preoperative imaging in renal cell cancer

A Heidenreich et al.

WORLD JOURNAL OF UROLOGY (2004)

Article Cell Biology

Vacuolar H+-ATPase in human breast cancer cells with distinct metastatic potential:: distribution and functional activity

SR Sennoune et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2004)

Review Oncology

Why do cancers have high aerobic glycolysis?

RA Gatenby et al.

NATURE REVIEWS CANCER (2004)

Review Chemistry, Medicinal

Carbonic anhydrase inhibitors

CT Supuran et al.

MEDICINAL RESEARCH REVIEWS (2003)