Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 186, Issue 1, Pages 54-59Publisher
WILEY
DOI: 10.1111/bjh.15858
Keywords
chronic myeloid leukaemia; tyrosine kinase inhibitors; successful treatment discontinuation; innate CD8(+) T-cells; NK cells
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Funding
- INSERM
- CHU de Poitiers
- Universite de Poitiers
- Ligue contre le Cancer (Comites departementaux de la Vienne, de la Charente, de la Charente Maritime et des Deux-Sevres)
- Association pour la Recherche en Immunologie-Poitou-Charentes (ARIM-PC)
- le Canceropole Grand Sud-Ouest et le Groupement Interregional de Recherche Clinique et d'Innovation Sud-Ouest Outre-Mer (API-K 2017)
- INCa-DGOS 8658 [PRT-K 2015-052]
- Fondation Brystol-Meyers Squibb
- Region Nouvelle Aquitaine, and Sport Collection
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Immunological mechanisms of treatment-free remission (TFR) in chronic myeloid leukaemia (CML) are poorly defined and, to date, no correlation between successful TFR and CD8(+) T-cell subsets has been found. We analysed a new identified human subset of CD8(+) T-cells, namely innate CD8(+) T-cells, in CML patients with TFR >= 2 years. We demonstrated a dramatic increase of functionally active innate CD8(+) T-cells in these patients as compared to control subjects and patients in remission under tyrosine kinase inhibitors. Moreover, we found a positive correlation between frequencies of innate CD8(+) T-cells and natural killer cells, possibly representing a new innate biomarker profile of successful TFR.
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