Journal
AMERICAN JOURNAL OF OPHTHALMOLOGY
Volume 168, Issue -, Pages 164-176Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ajo.2016.05.008
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Funding
- THREE-YEAR ACTION PROGRAM OF SHANGHAI MUNICIPALITY FOR STRENGTHENING THE CONSTRUCtion of the Public Health System [GWIII-15, GWIV-13.2]
- National Natural Science Foundation of China [81402695]
- Shanghai Natural Science Foundation [15ZR1438400]
- Shanghai Municipal Health Bureau [20134263]
- Shanghai Hospital Development Center Municipal Hospital Newly Developing Advanced Technology Joint Research Projects [SHDC12012123]
- Key Discipline of Public Health-Eye health in Shanghai [15GWZK0601]
- Overseas High-end Research Team-Eye health in Shanghai
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PURPOSE: To investigate the choroidal and retinal thickness in myopic, emmetropic, and hyperopic Chinese children by swept-source longer-wavelength optical coherence tomography. DESIGN: Cross-sectional study. METHODS: Two-hundred and seventy-six schoolchildren aged 7-13 years underwent comprehensive ophthalmic examinations, including cycloplegic refraction, and swept-source optical coherence tomography measurements. The thickness of the choroid, retina, ganglion cell layer, and nerve fiber layer were compared among children of different refractive status. The topographic variation and factors related to the thickness of the choroid and retinal layers were analyzed. RESULTS: Compared to emmetropic subjects, those with myopia had a significantly thinner choroid in all regions (P < .01), and hyperopic subjects had a thicker choroid in most regions (P < .05). The myopic retinas were thinner than those of emmetropic or hyperopic subjects in the superior parafoveal and all 4 perifoveal subfields (P < .05), but no other subfields differed significantly among different refractive groups (P > .05). The axial length and refractive diopters were independently related to central foveal choroidal thickness (R-2 = 0.17, P < .01), while age and intraocular pressure were independently associated with central fovea retinal (R-2 = 0.15, P < .01) and ganglion cell layer thicknesses (R-2 = 0.10, P < .01) after adjustment for other systematic and ocular factors. Central foveal choroidal and retinal thickness were unrelated in children of different refractive status (P > .05). CONCLUSIONS: Choroidal thickness, but not retinal thickness, correlated closely with axial length and refractive diopters in Chinese children. Choroid thinning occurs before retina thinning early in myopic progression. (C) 2016 The Author(s). Published by Elsevier Inc.
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