Journal
BRAIN RESEARCH
Volume 1707, Issue -, Pages 172-183Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2018.11.015
Keywords
Adenosine; Brain ischemia; Limb ischemic preconditioning; Hippocampus; Neuroprotection
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Funding
- National Natural Science Foundation of China [31100781]
- Natural Science Foundation of Hebei Province, PR China [C2011206040]
- Department of Health of Hebei Province [20090313]
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Our previous studies have demonstrated that limb ischemic preconditioning (LIP) induced brain ischemic tolerance and up-regulated the expression of p38 MAPK and ERK in the hippocampal CA1 region in rats. The present study was undertaken to investigate the role of adenosine in brain protection and up-regulation of p38 MAPK and ERK induced by LIP. It was found that adenosine A1 receptor antagonist DPCPX dose-dependently inhibited the protective effect of LIP. The up-regulation of p38 MAPK and ERK induced by LIP could be blocked by DPCPX. Furthermore, we observed the effect of adenosine on the brain ischemia. The results showed that pre-administration of adenosine could partly mimic the neuroprotective effect on the brain, up-regulate the expression of p38 MAPK and ERK. Based on the above results, it can be concluded that adenosine participated in brain protection and up-regulation of the expression of p38 MAPK and ERK during the induction of brain ischemic tolerance after LIP.
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