Journal
BMC MEDICAL GENOMICS
Volume 12, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12920-019-0487-6
Keywords
Long non-coding RNA; lncRNA; Hereditary disease; Gene regulation; Medical genetics
Categories
Funding
- Russian Ministry of Science and Education [28.12487.2018/12.1]
Ask authors/readers for more resources
BackgroundThousands of long non-coding RNA (lncRNA) genes are annotated in the human genome. Recent studies showed the key role of lncRNAs in a variety of fundamental cellular processes. Dysregulation of lncRNAs can drive tumorigenesis and they are now considered to be a promising therapeutic target in cancer. However, how lncRNAs contribute to the development of hereditary diseases in human is still mostly unknown.ResultsThis review is focused on hereditary diseases in the pathogenesis of which long non-coding RNAs play an important role.ConclusionsFundamental research in the field of molecular genetics of lncRNA is necessary for a more complete understanding of their significance. Future research will help translate this knowledge into clinical practice which will not only lead to an increase in the diagnostic rate but also in the future can help with the development of etiotropic treatments for hereditary diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available