Journal
BLOOD
Volume 133, Issue 18, Pages 1943-1952Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2018-10-808873
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Funding
- National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases [R01 DK102890]
- National Institute of General Medical Sciences [R01GM112792]
- National Institutes of Health, National Heart, Lung, and Blood Institute [R01HL136255]
- National Cancer Institute [R01CA205975]
- New York State Stem Cell Science (NYSTEM) Investigator Initiated Research Projects (IIRP) grant [C32602GG]
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The hematopoietic system produces new blood cells throughout life. Mature blood cells all derived from a pool of rare long-lived hematopoietic stem cells (HSCs) that are mostly quiescent but occasionally divide and self-renew to maintain the stem cell pool and to insure the continuous replenishment of blood cells. Mitochondria have recently emerged as critical not only for HSC differentiation and commitment but also for HSC homeostasis. Mitochondria are dynamic organelles that orchestrate a number of fundamental metabolic and signaling processes, producing most of the cellular energy via oxidative phosphorylation. HSCs have a relatively high amount of mitochondria that are mostly inactive. Here, we review recent advances in our understanding of the role of mitochondria in HSC homeostasis and discuss, among other topics, how mitochondrial dynamism and quality control might be implicated in HSC fate, self-renewal, and regenerative potential.
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