4.7 Review

Electroconductive materials as biomimetic platforms for tissue regeneration

Journal

BIOTECHNOLOGY ADVANCES
Volume 37, Issue 3, Pages 444-458

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2019.02.011

Keywords

Electroconductive material; Biomimetic templates; Tissue engineering; Nanomaterials; Stem cell

Funding

  1. CIHR operating grant
  2. NSERC Discovery grant program
  3. NSERC
  4. University of Ottawa
  5. CONICYT [74180020]

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In many diseases, tissue regeneration is compromised and/or insufficient to restore tissue/organ function. Therefore, novel regenerative therapies are being developed to enhance resident and transplanted cell proliferation and functional differentiation. Numerous biomaterials engineered to include nanocomponents have emerged as promising candidates to fulfil the need of mimicking the properties of the healthy extracellular matrix. This is particularly important for tissues that require electroconductive support to achieve optimal cellular function, such as muscles and neurons. In this review, we summarize and discuss the current state-of-theart for electroconductive materials in tissue regeneration, with particular emphasis on materials containing nanocomponents.

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