Journal
BIOSENSORS & BIOELECTRONICS
Volume 127, Issue -, Pages 118-125Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2018.12.005
Keywords
Electrolyte-Gated Organic Field Effect; Transistor; Peptide sensor; Cu2+ detection
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Funding
- ANR (Agence Nationale de la Recherche) through Labex SEAM (Science and Engineering for Advanced Materials and devices) [ANR 11 LABX 086, ANR 11 IDEX 05 02]
- CGI (Commissariat a l'Investissement d'Avenir) through Labex SEAM (Science and Engineering for Advanced Materials and devices) [ANR 11 LABX 086, ANR 11 IDEX 05 02]
- USTH (University of Science and Technology of Hanoi), Vietnam
- University Paris Diderot, France
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This work proposes an approach for Cu2+ sensing in water which combines the selectivity of the Gly-Gly-His (GGH) peptide probe with the sensitivity of the electrolyte-gated organic field-effect transistor (EGOFET). The oligopeptide probe was immobilized onto the gate electrode of the transistor by electrooxidation of the primary amine of the glycine moiety. Cu2+ complexation by the grafted GGH was at first electrochemically evidenced, using cyclic and square wave voltammetries, then it was demonstrated that GGH-functionalized EGOFETs can transduce Cu2+ complexation through a significant threshold voltage shift and therefore a change in drain current. The limit of detection is ca. 10-12 M and the sensitivity in the linear range (10(-12) - 10(-8) M) is 1 mA dec(-2) (drain current variations).
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