4.4 Article

SKO1 deficiency extends chronological lifespan in Saccharomyces cerevisiae

Journal

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 83, Issue 8, Pages 1473-1476

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/09168451.2019.1571901

Keywords

Saccharomyces cerevisiae; Sko1; lifespan; osmotic stress; oxidative stress

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Sko1 plays a key role in the control of gene expression by osmotic and oxidative stress in yeast. We demonstrate that the decrease in chronological lifespan (CLS) of hog1 Delta cells was suppressed by SKO1 deletion. sko1 Delta single mutant cells were shown to have a longer CLS, thus implicating Sko1 in the regulation of their CLS.

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