Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 111, Issue -, Pages 568-578Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2018.12.054
Keywords
Diabetes mellitus; Carvacrol; Testis tissue; Oxidative stress markers; Apoptotic genes; Germ cell apoptosis
Funding
- Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran [59341]
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Background: Diabetes is one of the most chronic and widespread diseases causing the damages to the male reproductive system. Nowadays, several studies have been performed to show the role of phenolic compounds in reducing the complications of diabetes. Carvacrol is a phenolic monoterpene which has been shown to have much therapeutic efficacy in various diseases. Methods: Thirty-two adult male Wistar rats (n = 8 in each group) were used in this experimental study. The induction of diabetes was performed using a single intraperitoneal (IP) injection of STZ (50 mg/kg). Rats were assigned into the following groups: control group, diabetic group, diabetic group daily fed with carvacrol at a dose of 75 mg/kg for 8 weeks, and the control group daily fed with carvacrol at a dose of 75 mg/kg for 8 weeks. Results: Treatment with carvacrol significantly improved the histological morphology of the testis, reduced the tissue activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzymes, and diminished the elevated levels of tissue malondialdehyde (MDA) (p < 0.05). Moreover, our results showed that carvacrol significantly decreased Bax and increased Bcl-2 at the levels of gene and protein expression. It also significantly (p < 0.05) reduced the rate of germ cell apoptosis. Conclusion: It seems that the treatment with carvacrol mitigates testicular tissue damage in diabetic rats possibly through its antioxidant properties.
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