Journal
BIOLOGICAL CHEMISTRY
Volume 396, Issue 9-10, Pages 1083-1089Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2015-0150
Keywords
antibiotic resistance; proton-motive force; transport; tripartite efflux pumps
Categories
Funding
- German Research Foundation [SFB 807, FOR2251]
- DFG-EXC115 (Cluster of Excellence Macromolecular Complexes at the Goethe University Frankfurt)
- Innovative Medicines Initiative Joint Undertaking Project Translocation (IMI-Translocation)
- EU Marie Curie Actions ITN
- Human Frontiers Science Program (HFSP)
- German-Israeli Foundation (GIF)
Ask authors/readers for more resources
In Gram-negative bacteria, tripartite efflux pumps, like AcrAB-TolC from Escherichia coli, play a prominent role in the resistance against multiple antibiotics. Transport of the drugs across the outer membrane and its coupling to the electrochemical gradient is dependent on the presence of all three components. As the activity of the E. coli AcrAB-TolC efflux pump is dependent on both the concentration of substrates and the extent of the electrochemical gradient across the inner membrane, the -dynamics of tripartite pump assembly and disassembly might be crucial for effective net transport of drugs towards the outside of the cell.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available