Journal
BIOMATERIALS
Volume 195, Issue -, Pages 51-62Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2018.12.029
Keywords
CO gas therapy; Carbon nanoparticles; Synergistic treatment; MOFs; Dual-mode imaging
Funding
- National Key R&D Program of China [2018YFA0507501]
- National Natural Science Foundation of China [21425518, 81671815, 81301974]
- Key Laboratory of Smart Drug Delivery [SDD2017-03]
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Carbon monoxide (CO) gas therapy combined with chemotherapy and photothermal therapy (PIT) is a promising treatment mode for malignant tumor. Herein, we firstly reported doxorubicin (DOX) loaded Mn carbonyl modified Fe (III)-based nanoMOFs (MIL-100) coated PEGylated magnetic carbon nanoparticles (denoted as MCM@PEG-CO-DOX NPs) as theranostics nanoplatforms for near-infrared (NIR)-responded CO-DOX combination therapy. MIL-100 as a good nanocarrier of DOX with high loading capacity can also chelate the Mn carbonyl after a smart modification. Meanwhile, magnetic carbon core possessed photothermal effect, which can convert the NIR light to heat by an 808 nm laser irradiation, resulting in the on-demand release of CO and DOX. As a result, combining with PTT, MCM@PEG-CO-DOX NPs killed tumor efficiently. Moreover, our synthesized MCM@PEG-CO-DOX NPs were capable of realizing tumor dual-mode imaging including magnetic resonance imaging (MRI) and photoacoustic imaging (PAI).
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