Journal
BIOCHEMISTRY-MOSCOW
Volume 84, Issue 3, Pages 205-219Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0006297919030039
Keywords
Pcbp1-4; hnRNP-K; gene expression; cell cycle; cancer; embryonic development; pluripotent stem cells
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Funding
- Russian Science Foundation [17-14-01407]
- Russian Science Foundation [17-14-01407] Funding Source: Russian Science Foundation
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Five known members of the family of KH-domain poly(C)-binding proteins (Pcbp1-4, hnRNP-K) have an unusually broad spectrum of cellular functions that include regulation of gene transcription, regulation of pre-mRNA processing, splicing, mRNA stability, translational silencing and enhancement, the control of iron turnover, and many others. Mechanistically, these proteins act via nucleic acid binding and protein-protein interactions. Through performing these multiple tasks, the KH-domain poly(C)-binding family members are involved in a wide variety of biological processes such as embryonic development, cell differentiation, and cancer. Deregulation of KH-domain protein expression is frequently associated with severe developmental defects and neoplasia. This review summarizes progress in studies of the KH-domain proteins made over past two decades. The review also reports our recent finding implying an involvement of the KH-factor Pcbp1 into control of transition from naive to primed pluripotency cell state.
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