Journal
AUTOPHAGY
Volume 15, Issue 10, Pages 1682-1693Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2019.1596479
Keywords
Autophagy-dependent secretion; cancer; IL1B; infection; neurodegeneration; secretory autophagy
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Funding
- University of Kansas Cancer Center [CCSG P30CA168524]
- NIH [CA227838]
- NIH Clinical and Translational Science Award grant [UL1TR000001]
- internal Lied Basic Science Grant Program of the KUMC Research Institute
- KUMC Biomedical Research Training Program
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Although best understood as a degradative pathway, recent evidence demonstrates pronounced involvement of the macroautophagic/autophagic molecular machinery in cellular secretion. With either overexpression or inhibition of autophagy mediators, dramatic alterations in the cellular secretory profile occur. This affects secretion of a plethora of factors ranging from cytokines, to granule contents, and even viral particles. Encompassing a wide range of secreted factors, autophagy-dependent secretion is implicated in diseases ranging from cancer to neurodegeneration. With a growing body of evidence shedding light onto the molecular mediators, this review delineates the molecular machinery involved in selective targeting of the autophagosome for either degradation or secretion. In addition, we summarize the current understanding of factors and cargo secreted through this unconventional route, and describe the implications of this pathway in both health and disease.
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