Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 42, Issue 5, Pages 383-392Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-019-01138-9
Keywords
Astrocyte; Hypothalamus; Inflammation; Microglia; Obesity
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Funding
- National Research Foundation [2016R1C1B3012748, 2016R1A5A2008630]
- Korea Health Industry Development Institute [HI17C0745]
- Yonsei University College of Dentistry [2018-32-0007]
- National Research Foundation of Korea [2016R1C1B3012748] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Obesity is one of the worldwide prevalent disease caused by the imbalance between food intake and energy expenditure. Over a 100 years of research demonstrate that hypothalamus is the critical brain region regulating energy homeostasis, and evidences suggest the participation of non-neuronal populations such as astrocytes and microglia in the regulation of energy homeostasis. Recently, fat-rich diet induced hypothalamic inflammation has been found to deregulate the energy homeostasis, leading to the insulin resistance, glucose intolerance, and obesity. Several underlying mechanisms have been proposed, yet compelling evidences require further elucidations. This review discusses the up to date proposed mechanisms by which fat-rich diet induces hypothalamic inflammation and obesity.
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