Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 42, Issue 2, Pages 150-158Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-019-01125-0
Keywords
Apoptosis; CD44v6; Imaging; PD-L1; Phage display; Pro-apoptotic peptide; Targeted therapeutics
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Funding
- National Research Foundation [NRF- 2014R1A5A2009242, NRF-2018R1A2B200837]
- Bio & Medical Technology Development Program [2017M3A9G8083382]
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Peptides have advantages over antibodies in terms of deep tissue penetration, low immunogenicity, and cost-effective production, but they have short circulation time and poor stability in vivo. Peptides have been extensively used as targeting moieties for the delivery of drug-loaded nanoparticles and function as targeted therapeutics in cancer treatment. Here, we review peptides that are exploited as targeted therapeutics in cancer therapy and apoptosis imaging probes for the monitoring of treatment responses.
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