Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 63, Issue 5, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00107-19
Keywords
KPC; Klebsiella; colistin; heteroresistance; hypermucoviscous
Categories
Funding
- Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Disease award
- NIH [AI141883]
- Emerging Infections Program
- National Center for Emerging and Zoonotic Infectious Diseases at the U.S. Centers for Disease Control and Prevention
- VA Merit Award [I01 BX002788]
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The convergence of hypervirulence and multidrug resistance in Klebsiella pneumoniae is a significant concern. Here, we report the first screen for hypermucoviscosity, a trait associated with increased virulence, using a U.S. surveillance collection of carbapenem- resistant (CR) K. pneumoniae isolates. We identified one hypermucoviscous isolate, which carried a gene encoding the KPC-3 carbapenemase, among numerous resistance genes. The strain further exhibited colistin heteroresistance undetected by diagnostics. This convergence of diverse resistance mechanisms and increased virulence underscores the need for enhanced K. pneumoniae surveillance.
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