Journal
ANTICANCER RESEARCH
Volume 39, Issue 2, Pages 541-548Publisher
INT INST ANTICANCER RESEARCH
DOI: 10.21873/anticanres.13146
Keywords
Integrin; target therapy; anti-cancer drug; lung cancer; drug discovery; review
Categories
Funding
- Grant for International Research Integration: Ratchadaphiseksomphot Endowment Fund
Ask authors/readers for more resources
Integrins are cell-matrix adhesion molecules providing both mechanical engagement of cell to extracellular matrix, and generation of cellular signals that are implicated in cancer malignancies. The concept that integrins play important roles in cell survival, proliferation, motility, differentiation, and ensuring appropriate cell localization, leads to the hypothesis that inhibition of certain integrins would benefit cancer therapy. In lung cancer, integrins alpha v, alpha 5, beta 1, beta 3, and beta 5 have been shown to augment survival and metastatic potential of cancer cells. This review presents data suggesting integrins as molecular targets for anti-cancer approaches, and the mechanisms through which integrins confer resistance of lung cancer to chemotherapeutics and metastasis. The better understanding of these key molecules may benefit the discovery of anti-cancer drugs and strategies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available