Journal
ANNALS OF ONCOLOGY
Volume 30, Issue 3, Pages 374-384Publisher
OXFORD UNIV PRESS
DOI: 10.1093/annonc/mdz031
Keywords
cancer; circulating DNA; diagnostic; treatment; resistance; screening
Categories
Funding
- SFAC (Societe Francaise des Acides Nucleiques Circulants/French Society of Circulating Nucleic Acids)
- University of Montpellier (France)
- GSO canceropole (France)
- Languedoc-Roussillon region (France)
- Lilly (France)
- SIRIC Montpellier Grant (INCa-DGOS Inserm 6045), France
- European Union's Horizon 2020 research and innovation program [755333]
- INSERM (Institut National de la Sante et de la Recherche Medicale, France)
- H2020 Societal Challenges Programme [755333] Funding Source: H2020 Societal Challenges Programme
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Circulating cell-free DNA (cfDNA) is one of the fastest growing and most exciting areas in oncology in recent years. Its potential clinical uses cover now each phase of cancer patient management care (predictive information, detection of the minimal residual disease, early detection of resistance, treatment monitoring, recurrence surveillance, and cancer early detection/screening). This review relates the recent advances in the application of circulating DNA or RNA in oncology building on unpublished or initial findings/work presented at the 10th international symposium on circulating nucleic acids in plasma and serum held in Montpellier from the 20th to the 22nd of September 2017. This year, presenters revealed their latest data and crucial observations notably in relation to (i) the circulating cell-free (cfDNA) structure and implications regarding their optimal detection; (ii) their role in the metastatic or immunological processes; (iii) evaluation of miRNA panels for cancer patient follow up; (iv) the detection of the minimal residual disease; (v) the evaluation of a screening tests for cancer using cfDNA analysis; and (vi) elements of preanalytical guidelines. This work reviews the recent progresses in the field brought to light in the meeting, as well as in the most important reports from the literature, past and present. It proposes a broader picture of the basic research and its potential, and of the implementation and current challenges in the use of circulating nucleic acids in oncology.
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