Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 15, Pages 4911-4916Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201813994
Keywords
antibacterial effect; peroxidase-like activity; single-atom nanozyme; unsaturated Zn-N-4 sites
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Funding
- National Natural Science Foundation of China [21822802, 81671810, 51772018, 51572271, 31871005, 31530026]
- National Basic Research Program of China (973 Program) [2016YFA0201500]
- Fundamental Research Funds for the Central Universities [buctrc201610, PYBZ1825, XK1901, XK1802-8]
- Young Elite Scientist Sponsorship Program by CAST [2015QNRC001]
- Key Research Program of Frontier Sciences [QYZDY-SSW-SMC013]
- Strategic Priority Research Program, CAS [XDB29040101]
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Single-atom catalysts (SACs), as homogeneous catalysts, have been widely explored for chemical catalysis. However, few studies focus on the applications of SACs in enzymatic catalysis. Herein, we report that a zinc-based zeolitic-imidazolate-framework (ZIF-8)-derived carbon nanomaterial containing atomically dispersed zinc atoms can serve as a highly efficient single-atom peroxidase mimic. To reveal its structure-activity relationship, the structural evolution of the single-atom nanozyme (SAzyme) was systematically investigated. Furthermore, the coordinatively unsaturated active zinc sites and catalytic mechanism of the SAzyme are disclosed using density functional theory (DFT) calculations. The SAzyme, with high therapeutic effect and biosafety, shows great promises for wound antibacterial applications.
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