Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 15, Pages 5064-5068Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201812100
Keywords
ammonia; carbonyl compounds; nickel nanoparticles; primary amines; reductive amination
Categories
Funding
- European Research Council (EU) [670986-NoNaCat]
- State of Mecklenburg-Vorpommern
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The preparation of nickel nanoparticles as efficient reductive amination catalysts by pyrolysis of in situ generated Ni-tartaric acid complex on silica is presented. The resulting stable and reusable Ni-nanocatalyst enables the synthesis of functionalized and structurally diverse primary benzylic, heterocyclic and aliphatic amines starting from inexpensive and readily available carbonyl compounds and ammonia in presence of molecular hydrogen. Applying this Ni-based amination protocol, -NH2 moiety can be introduced in structurally complex compounds, for example, steroid derivatives and pharmaceuticals.
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