Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 14, Pages 4557-4561Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201813935
Keywords
endogenous biothiols; fluorescent probe; simultaneous sensing; transformation
Categories
Funding
- National Natural Science Foundation of China [21877035, 31872540, 21675051]
- Opening Fund of Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), Hunan Normal University
- Science and Technology Planning Project of Hunan Province [2018TP1017]
- K.C. Wong Magna Fund in Ningbo University
- Ningbo Programs for Science and Technology Development [2017C110026]
Ask authors/readers for more resources
Studying numerous biologically important species simultaneously is crucial to understanding cellular functions and the root causes of related diseases. Direct visualization of endogenous biothiols in biological systems is of great value to understanding their biological roles. Herein, a novel multi-signal fluorescent probe was rationally designed and exploited for the simultaneous sensing of homocysteine (Hcy), cysteine (Cys), and glutathione (GSH) using different emission channels. This probe was successfully applied to the simultaneous discrimination between and visualization of endogenous Hcy, Cys, GSH, and their transformation in living cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
