Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 21, Pages 7078-7082Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201902817
Keywords
drug release; metal-organic frameworks; nanocomposites; thermoplasmonics; ZIF-8
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Funding
- MINECO-Spain [MAT2016-80266-R, MAT2015-74381-JIN, CTQ2017-88648R, ENE2016-79608-C2-1-R, CTQ2017-89588-R, RYC-2014-15039, RYC-2014-16962]
- Xunta de Galicia, Centro singular de investigacion de Galicia [ED431G/09]
- Agrupacion Estrategica de Materiales Action [ED431E 2018/08]
- Generalitat de Cataluna [2017SGR522, 2017SGR883, SLT002/16/00239]
- URV [2017PFR-URV-B2-02]
- German Research Society [DFG PA 794-21-1]
- European Union (European Regional Development Fund-ERDF) [749667]
- CONACYT
- Marie Curie Actions (MSCA) [749667] Funding Source: Marie Curie Actions (MSCA)
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A plasmonic core-shell gold nanostar/zeolitic-imidazolate-framework-8 (ZIF-8) nanocomposite was developed for the thermoplasmonic-driven release of encapsulated active molecules inside living cells. The nanocomposites were loaded, as a proof of concept, with bisbenzimide molecules as functional cargo and wrapped with an amphiphilic polymer that prevents ZIF-8 degradation and bisbenzimide leaking in aqueous media or inside living cells. The demonstrated molecule-release mechanism relies on the use of near-IR light coupled to the plasmonic absorption of the core gold nanostars, which creates local temperature gradients and thus, bisbenzimide thermodiffusion. Confocal microscopy and surface-enhanced Raman spectroscopy (SERS) were used to demonstrate bisbenzimide loading/leaking and near-IR-triggered cargo release inside cells, thereby leading to DNA staining.
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