Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 12, Pages 3870-3874Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201813917
Keywords
boronic esters; cascade; cyclobutanes; photoredox catalysis; radical-polar crossover
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Funding
- EPSRC [EP/I038071/1]
- H2020 ERC [670668]
- BBSRC [BB/F011539/1] Funding Source: UKRI
- EPSRC [EP/L011999/1, EP/I038071/1] Funding Source: UKRI
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Photoredox-catalyzed methylcyclobutanations of alkylboronic esters are described. The reactions proceed through single-electron transfer induced deboronative radical addition to an electron-deficient alkene followed by single electron reduction and polar 4-exo-tet cyclization with a pendant alkyl halide. Key to the success of the methodology was the use of easily oxidizable arylboronate complexes Structurally diverse cyclobutanes are shown to be conveniently prepared from readily available alkylboronic esters and a range of haloalkyl alkenes. The mild reactions display excellent functional group tolerance, and the radical addition-polar cyclization cascade also enables the synthesis of 3-, 5-, 6-, and 7-membered rings.
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