Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 37, Pages 12761-12777Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201900932
Keywords
ACDC; Bronsted acids; enantioselective catalysis; Lewis acids; organocatalysis; silylium ions
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Funding
- H2020 European Research Council [CHAOS] Funding Source: Medline
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High acidity and structural confinement are pivotal elements in asymmetric acid catalysis. The recently introduced imidodiphosphorimidate (IDPi) Bronsted acids have met with remarkable success in combining those features, acting as powerful Bronsted acid catalysts and silylium Lewis acid precatalysts in numerous thus far inaccessible transformations. Substrates as challenging to activate as simple olefins were readily transformed, ketones were employed as acceptors in aldolizations allowing sub-ppm level catalysis, whereas enolates of the smallest donor aldehyde, acetaldehyde, did not polymerize but selectively added a single time to a variety of acceptor aldehydes.
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